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Fludarabine therapy in patients with splenic lymphoma with villous lymphocytes: an update

Leukemia volume 18, pages 1924–1925 (2004)Cite this article

TO THE EDITOR

Splenic lymphoma with villous lymphocytes (SLVL) is usually an indolent mature B-cell lymphoproliferative disorder (B-CLD) recognized as a variant of marginal zone lymphoma.1 The main characteristics are the presence of massive splenomegaly and absolute lymphocytosis with circulating villous lymphoid cells (VL). Splenectomy or chlorambucil (CLB) are regarded as the most effective treatment, particularly in patients with symptomatic splenomegaly, rapid increase of lymphocyte or severe pancytopenia.2 However, splenectomy sometimes carries surgical risks; CLB is often not effective and relapse is frequent.

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Authors and Affiliations

  1. Service d'Hématologie Adultes, Hôpital Necker, Paris, France

    F Lefrère, R Delarue, B Varet & O Hermine

  2. Centre d'investigation Clinique, Hôpital Saint-Louis, Paris, France

    V Lévy

  3. Service des Maladies du Sang, Centre Hopitalier-Universitaire, Angers, France

    S François & N Ifrah

  4. Département d'Hématologie, Centre Henri Becquerel, Rouen, France

    H Tilly

  5. Laboratoire d'Hématologie, Hôpital Necker, Paris, France

    F Valensi

  6. Laboratoire d'Hématologie, Centre Hospitalier-Universitaire, Caen, France

    X Troussard

Authors
  1. F Lefrère
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  2. V Lévy
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  3. S François
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  4. R Delarue
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  5. N Ifrah
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  6. H Tilly
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  7. F Valensi
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  8. X Troussard
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  9. B Varet
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  10. O Hermine
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Correspondence to F Lefrère.

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Lefrère, F., Lévy, V., François, S. et al. Fludarabine therapy in patients with splenic lymphoma with villous lymphocytes: an update. Leukemia 18, 1924–1925 (2004). https://doi.org/10.1038/sj.leu.2403440

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  • DOI: https://doi.org/10.1038/sj.leu.2403440

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