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Circulating myeloid and lymphoid precursor dendritic cells are clonally involved in myelodysplastic syndromes

Leukemia volume 18, pages 1451–1456 (2004)Cite this article

Abstract

Circulating myeloid and lymphoid precursor dendritic cell (pDC) counts were determined in peripheral blood from 22 patients with myelodysplastic syndromes (MDS) by a single-platform flow cytometric protocol. The absolute count of myeloid and lymphoid pDC, as well as their relative number (as proportion of mononuclear cells or total leukocytes) was significantly lower in MDS (n=22) than in healthy controls (n=41). In 11 patients with chromosomal aberrations, purified pDC were examined by interphase fluorescence in situ hybridization. This revealed clonal involvement of myeloid as well as lymphoid pDC in all of them. These data therefore strongly suggest that myeloid and lymphoid pDC share a common precursor. Whether reduced peripheral blood counts of pDC contribute to the immunological abnormalities observed in MDS remains to be investigated.

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Acknowledgements

PV and MD are senior clinical investigators of Fonds voor Wetenschappelijk Onderzoek-Vlaanderen. This research was supported by grant OT/00/23 of the Research Council of the Catholic University of Leuven, grant G.0370.01 from Fonds voor Wetenschappelijk Onderzoek-Vlaanderen, by the Belgian Programme of Interuniversity Poles of Attraction, initiated by the Belgian State, Prime Minister's Office, Science Policy Programming, and by the Steverlynck Leerstoel voor Hematologie. The scientific responsibility is assumed by the authors.

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Authors and Affiliations

  1. Laboratory for Experimental Hematology, University of Leuven, Leuven, Belgium

    L Ma, M Delforge, V Van Duppen, G Verhoef, M Boogaerts & P Vandenberghe

  2. Center for Human Genetics, University of Leuven, Leuven, Belgium

    B Emanuel, A Hagemeijer & P Vandenberghe

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  1. L Ma
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  2. M Delforge
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Correspondence to P Vandenberghe.

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Ma, L., Delforge, M., Van Duppen, V. et al. Circulating myeloid and lymphoid precursor dendritic cells are clonally involved in myelodysplastic syndromes. Leukemia 18, 1451–1456 (2004). https://doi.org/10.1038/sj.leu.2403430

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