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ETV6 (TEL) gene amplification in a myelodysplastic syndrome with excess of blasts

Leukemia volume 18, pages 1436–1438 (2004)Cite this article

TO THE EDITOR

Oncogene amplifications are frequent events in solid tumors, observed either as large chromosomes in which the amplified DNA appears as a homogeneous stained region (hsr) or as small chromosomal structures described as double minute chromosomes (dmin). In malignant hemopathies, such chromosomal alterations are rather rare, concerning a limited number of genes often implicated in recurrent translocations. Amplifications, now more easily detected by extensive use of FISH and/or comparative genomic hybridization, involve in majority c-MYC, MLL1 and RUNX1 (AML1)2 genes, more rarely other sequences. We report here the amplification of ETV6 gene, diagnosed with FISH and quantitative PCR, in a myelodysplastic syndrome with excess of blasts.

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Authors and Affiliations

  1. Laboratoire d'Hématologie, Hôpital Hautepierre, Strasbourg, France

    L Mauvieux, C Helias & M Lessard

  2. Laboratoire d'Hématologie Cellulaire, Université Louis Pasteur, Strasbourg, France

    L Mauvieux, N Perrusson & M Lessard

  3. Département d'Onco-hématologie, Hôpital Hautepierre, Strasbourg, France

    B Lioure

  4. Laboratoire d'Hématologie, CHU la Milétrie, Poitiers, France

    N Sorel & F Brizard

Authors
  1. L Mauvieux
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  2. C Helias
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  7. M Lessard
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Correspondence to M Lessard.

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Mauvieux, L., Helias, C., Perrusson, N. et al. ETV6 (TEL) gene amplification in a myelodysplastic syndrome with excess of blasts. Leukemia 18, 1436–1438 (2004). https://doi.org/10.1038/sj.leu.2403403

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  • DOI: https://doi.org/10.1038/sj.leu.2403403

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