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Somatic PTPN11 mutation with a heterogeneous clonal origin in children with juvenile myelomonocytic leukemia

Leukemia volume 18, pages 1142–1144 (2004)Cite this article

TO THE EDITOR

Juvenile myelomonocytic leukemia (JMML) is a clonal myeloproliferative disorder seen in young children and is characterized by leukocytosis with monocytosis, thrombocytopenia, hepatosplenomegaly, and elevated fetal hemoglobin caused by a reversion to fetal-like erythropoiesis.1 The Ras signaling pathway is known to be deregulated by mutations in the RAS gene or the neurofibromatosis type 1 gene (NF1) in approximately 40% of JMML cases.

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Acknowledgements

This work was supported by Pfizer Fund for Growth & Development Research, the Program for the Promotion of Fundamental Studies in Health Sciences of the Organization for Drug ADR Relief, R&D Promotion, and Product Review of Japan, and the Grant for Clinical Research for Evidence Based Medicine from the Ministry of Health, Labour, and Welfare of Japan. We thank C Hatanaka for her technical assistance.

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Authors and Affiliations

  1. Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan

    H Shimada, T Mori, N Shimasaki, T Takahashi & K Kosaki

  2. Molecular Oncology Division, National Cancer Center Research Institute, Tokyo, Japan

    K Shimizu

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  1. H Shimada
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  2. T Mori
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  3. N Shimasaki
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  4. K Shimizu
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  5. T Takahashi
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  6. K Kosaki
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Correspondence to T Mori.

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Shimada, H., Mori, T., Shimasaki, N. et al. Somatic PTPN11 mutation with a heterogeneous clonal origin in children with juvenile myelomonocytic leukemia. Leukemia 18, 1142–1144 (2004). https://doi.org/10.1038/sj.leu.2403374

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  • DOI: https://doi.org/10.1038/sj.leu.2403374

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