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TNF-α receptor 1 expression on acute myeloid leukemic blasts predicts differentiation into leukemic dendritic cells

Leukemia volume 18, pages 1149–1153 (2004)Cite this article

TO THE EDITOR

Dendritic cells (DC) are the most powerful antigen-presenting cells, capable of activating naïve T cells. Leukemic blasts have the unique ability to differentiate into leukemic DC, thereby conserving their intrinsic leukemia antigen repertoire and obtaining full potential of antigen presentation. We have shown that DC generated from acute myeloid leukemic (AML) blasts are able to initiate autologous cytotoxic T-cell responses, and thus hold promise for vaccination purposes in a minimal residual disease (MRD) status.1 In a recently performed phase-I study on CML-DC vaccination in advanced stage chronic myeloid leukemia (CML), we were able to detect strong DTH-responses representing autologous CML-specific T-cell responses.2

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Authors and Affiliations

  1. Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands

    I Houtenbos, T M Westers, G J Ossenkoppele & A A van de Loosdrecht

  2. Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands

    T D de Gruijl

  3. Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands

    R J Scheper

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  1. I Houtenbos
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  2. T M Westers
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  3. T D de Gruijl
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  4. R J Scheper
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  5. G J Ossenkoppele
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  6. A A van de Loosdrecht
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Correspondence to A A van de Loosdrecht.

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Houtenbos, I., Westers, T., de Gruijl, T. et al. TNF-α receptor 1 expression on acute myeloid leukemic blasts predicts differentiation into leukemic dendritic cells. Leukemia 18, 1149–1153 (2004). https://doi.org/10.1038/sj.leu.2403359

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