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Crosstalk between angiogenesis and lymphangiogenesis in tumor progression

Leukemia volume 18, pages 1054–1058 (2004)Cite this article

Abstract

Extensive studies have identified reliable markers of lymphatic endothelial cells, and mechanisms and molecules that regulate development and growth of the lymphatic vessels. Vascular endothelial growth factors (VEGF)-C and VEGF-D, and their cognate receptor tyrosine kinase, VEGF receptor-3 (VEGFR-3), are critical regulators of lymphangiogenesis. By binding to its endothelial cell surface receptors VEGFR-1 and VEGFR-2, VEGF-A mediates vascular leakage, endothelial proliferation and migration. Angiopoietin-2 (Ang-2) is expressed at sites of blood vessel remodeling and invasion, and factors that induce angiogenesis in vivo, such as VEGF-A, upregulate Ang-2 in endothelial cells. In this review, we summarize the literature concerning the crosstalk between angiogenesis and lymphangiogenesis in tumor progression, that is, involvement of VEGF-C, VEGF-D and VEGFR-3 in angiogenesis, and the role played by VEGF-A and Ang-2 in lymphangiogenesis, respectively.

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Acknowledgements

This work is supported by Ministry for Education, the University and Research (MIUR, Interuniversity Funds for Basic Research (FIRB, Rome), Associazione Italiana per la Ricerca sul Cancro (AIRC, Milan) and Fondazione Italiana per la Lotta al Neuroblastoma (Genoa, Italy).

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Authors and Affiliations

  1. Deparment of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy

    C Scavelli, A Vacca, G Di Pietro & F Dammacco

  2. Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy

    D Ribatti

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  1. C Scavelli
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Correspondence to D Ribatti.

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Scavelli, C., Vacca, A., Di Pietro, G. et al. Crosstalk between angiogenesis and lymphangiogenesis in tumor progression. Leukemia 18, 1054–1058 (2004). https://doi.org/10.1038/sj.leu.2403355

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