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Abnormal mRNA expression of ASPP members in leukemia cell lines

Leukemia volume 18, page 880 (2004)Cite this article

TO THE EDITOR

Recently, Lu et al1,2 have discovered a new protein family that interferes with the working of p53. This family consists of three members: ASPP1, ASPP2 and iASPP. ASPP1 and ASPP2 act as potent activators of p53. iASPP acts as an inhibitor of p53. Their research proved that the apoptotic function of p53 is stimulated by ASPP1 and ASPP2 and inhibited by iASPP. The discovery of ASPP family may answer such questions as ‘how cells choose to die’.3,4

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References

  1. Bergamaschi D, Samuels Y, O'Neil NJ et al. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nat Genet 2003; 33: 162–167.

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  2. Samuels-Lev Y, O'Connor DJ, Bergamaschi D et al. ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell 2001; 8: 781–794.

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  3. Lane D . How cells choose to die. Nature 2001; 414: 25.

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  5. P53 mutation database. http://p53.curie.fr.

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Author notes

  1. Z-J Liu: No further comments have been received from Dr Lu et al

Authors and Affiliations

  1. Department of Laboratory Medicine, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China

    Z-J Liu, Y Zhang, X-B Zhang & X Yang

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  1. Z-J Liu
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  2. Y Zhang
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  3. X-B Zhang
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  4. X Yang
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Correspondence to Z-J Liu.

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Liu, ZJ., Zhang, Y., Zhang, XB. et al. Abnormal mRNA expression of ASPP members in leukemia cell lines. Leukemia 18, 880 (2004). https://doi.org/10.1038/sj.leu.2403300

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  • DOI: https://doi.org/10.1038/sj.leu.2403300

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