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Second malignancy after treatment of adult acute myeloid leukemia: cohort study on adult patients enrolled in the GIMEMA trials

Leukemia volume 18, pages 651–653 (2004)Cite this article

TO THE EDITOR

The risk of developing secondary tumors after treatment of hematological malignancies is well known and is especially relevant for diseases where chemo- and/or radiotherapy often warrant a long survival.1 In acute myeloid leukemia (AML) this is a rare event; however, a recent study demonstrated that in children treated for AML, surviving at long term, there is a 10-fold increased risk of development of cancer, indicating that AML treatment may enhance the risk of second malignancies (SMs).2 On the other hand, the Copenhagen Hematology group, analyzing 174 AML adult patients enrolled in anthracyclines-based trials, demonstrated that standardized incidence ratio (SIR) was not significantly influenced by intensive chemotherapy.3

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Acknowledgements

This work was supported in part by a grant from Ministry of University and Technological Research (MURST) of Italy.

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Authors and Affiliations

  1. Gruppo Italiano Malattie Ematologiche Adulto (GIMEMA),

    L Pagano, A Pulsoni, M E Tosti, C Caramatti, R Cerri, P Falcucci, P Fazi, L Fianchi, B Martino, D Mattei, M Offidani, L Pacilli, E M Pogliani, B Rotoli, G Specchia, G Visani, M Vignetti, M T Voso, G Leone & F Mandelli

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  1. L Pagano
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  2. A Pulsoni
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  3. M E Tosti
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  4. C Caramatti
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  6. P Falcucci
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  7. P Fazi
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  8. L Fianchi
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  9. B Martino
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  10. D Mattei
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  11. M Offidani
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  12. L Pacilli
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  13. E M Pogliani
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  14. B Rotoli
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  15. G Specchia
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  16. G Visani
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  17. M Vignetti
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  18. M T Voso
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  19. G Leone
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  20. F Mandelli
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Correspondence to L Pagano.

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Pagano, L., Pulsoni, A., Tosti, M. et al. Second malignancy after treatment of adult acute myeloid leukemia: cohort study on adult patients enrolled in the GIMEMA trials. Leukemia 18, 651–653 (2004). https://doi.org/10.1038/sj.leu.2403276

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  • DOI: https://doi.org/10.1038/sj.leu.2403276

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