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SOCS1 and SHP1 hypermethylation in mantle cell lymphoma and follicular lymphoma: implications for epigenetic activation of the Jak/STAT pathway

Leukemia volume 18, pages 356–358 (2004)Cite this article

TO THE EDITOR

Mantle cell lymphoma (MCL) and follicular lymphoma (FL) are two forms of B-cell lymphoma derived from neoplastic transformation of their normal counterparts in the mantle zone and germinal center, respectively.1 MCL is characterized in virtually all cases by t(11;14), with dysregulation of the cell cycle by upregulation of cyclin D1 located at 11q13.1 On the other hand, FL is characterized by t(14;18) and upregulation of BCL-2 located at 18q21, which confers resistance to apoptosis on the malignant lymphoid cells.1

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Acknowledgements

We express our sincere thanks to Dr Junjiro Tsuchiyama for the NK-YS cell line and all medical and nursing staff in the Department of Medicine, Queen Mary Hospital for the provision of expert medical care.

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Authors and Affiliations

  1. University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong

    C S Chim

  2. Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong

    K Y Wong, F Loong & G Srivastava

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  1. C S Chim
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Correspondence to C S Chim or G Srivastava.

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Chim, C., Wong, K., Loong, F. et al. SOCS1 and SHP1 hypermethylation in mantle cell lymphoma and follicular lymphoma: implications for epigenetic activation of the Jak/STAT pathway. Leukemia 18, 356–358 (2004). https://doi.org/10.1038/sj.leu.2403216

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