This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
First-in-human study of WT1 recombinant protein vaccination in elderly patients with AML in remission: a single-center experience
Cancer Immunology, Immunotherapy Open Access 27 April 2022
-
HLA class I-restricted T cell epitopes isolated and identified from myeloid leukemia cells
Scientific Reports Open Access 01 October 2019
-
Identification of TCR Vβ11-2-Dβ1-Jβ1-1 T cell clone specific for WT1 peptides using high-throughput TCRβ gene sequencing
Biomarker Research Open Access 14 June 2019
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Get just this article for as long as you need it
$39.95
Prices may be subject to local taxes which are calculated during checkout

References
Rosenfeld C, Cheever MA, Gaiger A . WT1 in acute leukemia, chronic myelogenous leukemia and myelodysplastic syndrome: therapeutic potential of WT1 targeted therapies. Leukemia 2003; 17: 1301–1312.
Menssen HD, Renkl HJ, Rodeck U, Maurer J, Notter M, Schwartz S et al. Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias. Leukemia 1995; 9: 1060–1067.
Inoue K, Tamaki H, Ogawa H, Oka Y, Soma T, Tatekawa T et al. Wilms' tumor gene (WT1) competes with differentiation-inducing signal in hematopoietic progenitor cells. Blood 1998; 91: 2969–2976.
Oka Y, Elisseeva OA, Tsuboi A, Ogawa H, Tamaki H, Li H et al. Human cytotoxic T-lymphocyte responses specific for peptides of the wild-type Wilms' tumor gene (WT1) product. Immunogenetics 2000; 51: 99–107.
Oka Y, Udaka K, Tsuboi A, Elisseeva OA, Ogawa H, Aozasa K et al. Cancer immunotherapy targeting Wilms' tumor gene WT1 product. J Immunol 2000; 164: 1873–1880.
Scheibenbogen C, Schadendorf D, Bechrakis N, Nagorsen D, Hofmann U, Servetopoulou F et al. Effects of granulocyte–macrophage colony-stimulating factor and foreign helper protein as immunologic adjuvants on the T-cell response to vaccination with tyrosinase peptides. Int J Cancer 2003; 104: 188–194.
Siehl J, Thiel E, Heufelder K, Snarsk E, Schwartz S, Mailander V et al. Regulation of Wilms' tumor gene 1(wt1) expression by the paired box genes PAX2 and PAX8 and by the hematopoietic transcription factor GATA-1 in human acute myeloid leukemias. Br J Hematol 2003; 123: 235–242.
Cilloni D, Gottardi E, De Micheli D, Serra A, Volpe G, Messa F et al. Quantitative assessment of WT1 expression by real time quantitative PCR may be a useful tool for monitoring minimal residual disease in acute leukemia patients. Leukemia 2002; 16: 2115–2121.
Menssen HD, Renkl HJ, Entezami M, Thiel E . Wilms' tumor gene expression in human CD34+ hematopoietic progenitors during fetal development and early clonogenic growth. Blood 1997; 89: 3486–3487.
Scheibenbogen C, Letsch A, Thiel E, Schmittel A, Mailaender V, Baerwolf S et al. CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia. Blood 2002; 100: 2132–2137.
Acknowledgements
This work is supported by a grant from the German José-Carreras Foundation.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mailänder, V., Scheibenbogen, C., Thiel, E. et al. Complete remission in a patient with recurrent acute myeloid leukemia induced by vaccination with WT1 peptide in the absence of hematological or renal toxicity. Leukemia 18, 165–166 (2004). https://doi.org/10.1038/sj.leu.2403186
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.leu.2403186
This article is cited by
-
Efficacy and safety of Wilms’ tumor 1 helper peptide OCV-501 in elderly patients with acute myeloid leukemia: a multicenter, randomized, double-blind, placebo-controlled phase 2 trial
Cancer Immunology, Immunotherapy (2022)
-
First-in-human study of WT1 recombinant protein vaccination in elderly patients with AML in remission: a single-center experience
Cancer Immunology, Immunotherapy (2022)
-
Identification of TCR Vβ11-2-Dβ1-Jβ1-1 T cell clone specific for WT1 peptides using high-throughput TCRβ gene sequencing
Biomarker Research (2019)
-
Alternative tumour-specific antigens
Nature Reviews Cancer (2019)
-
HLA class I-restricted T cell epitopes isolated and identified from myeloid leukemia cells
Scientific Reports (2019)