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DNA sequencing-based HLA typing detects a B-cell ALL blast-specific mutation in HLA-A*2402 resulting in loss of HLA allele expression

Leukemia volume 18, pages 174–176 (2004)Cite this article

TO THE EDITOR

We describe the detection of a single base pair insertion in the HLA-A*2402 allele in the blast cells of a patient with B-cell acute lymphoblastic leukemia (B-ALL). This mutation resulted in the loss of expression of HLA-A*2402 on the blast cells. The mutation was not present in the nonleukemia cells on which HLA-A*2402 was normally expressed. The mutation was detected following HLA typing by DNA sequencing during routine workup for bone marrow transplantation.

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Authors and Affiliations

  1. Department of Clinical Immunology and Biochemical, Genetics, Royal Perth Hospital, Perth, Western Australia

    D C Sayer, L K Smith & F T Chrisitansen

  2. School of Surgery and Pathology, University of Western, Australia, Nedlands, Western Australia

    D C Sayer & F T Chrisitansen

  3. Flow Cytometry Unit, Royal Perth Hospital, Perth, Western Australia

    R Krueger

Authors
  1. D C Sayer
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  2. L K Smith
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  3. R Krueger
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  4. F T Chrisitansen
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Sayer, D., Smith, L., Krueger, R. et al. DNA sequencing-based HLA typing detects a B-cell ALL blast-specific mutation in HLA-A*2402 resulting in loss of HLA allele expression. Leukemia 18, 174–176 (2004). https://doi.org/10.1038/sj.leu.2403150

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  • DOI: https://doi.org/10.1038/sj.leu.2403150

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