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Mechanisms of action of extracorporeal photochemotherapy in the control of GVHD: involvement of dendritic cells

Leukemia volume 17, pages 2061–2062 (2003)Cite this article

Abstract

Despite the fact that extracorporal photochemotherapy (ECP) is now broadly used for the treatment of graft versus host disease or T-cell lymphomas, the mechanisms of its action remain enigmatic. This work provides a synthesis of the main results suggesting the initiation by ECP of an immune reaction responsible for the down modulation of pathogenic T-cell functions, with a special focus on the role of dendritic cells in this phenomenon.

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Authors and Affiliations

  1. Department of Research and Development and Cell Therapy Unit, EFS Rhône-Alpes, CHU Michalon, UJF, GRENOBLE, France

    J Plumas, O Manches & L Chaperot

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  1. J Plumas
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  2. O Manches
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Plumas, J., Manches, O. & Chaperot, L. Mechanisms of action of extracorporeal photochemotherapy in the control of GVHD: involvement of dendritic cells. Leukemia 17, 2061–2062 (2003). https://doi.org/10.1038/sj.leu.2403114

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