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Recruitment of leukemic cells from G0 phase of the cell cycle by interferons results in conversion of resistance to daunorubicin

Leukemia volume 17, pages 2049–2051 (2003)Cite this article

TO THE EDITOR

Although the majority of patients with acute myeloid leukemia (AML) responds to initial treatment, relapse of the disease occurs in a significant percentage of these patients.1 The cell cycle status of leukemic cells may play an important role in the response to treatment of leukemic cells. Especially, the broadly used cytotoxic agent Cytarabine (Ara-C) has been demonstrated to exert its action via intercalation into the DNA of cells specifically in the S phase of the cell cycle, and sensitivity to this agent is therefore described to be specific for cells in active cell cycle.2 The role of the cell cycle in sensitivity of leukemic cells to anthracyclins like daunorubicin remains largely unknown.

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Authors and Affiliations

  1. Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands

    I Jedema, R M Y Barge, B A Nijmeijer, R Willemze & J H F Falkenburg

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  1. I Jedema
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  2. R M Y Barge
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  3. B A Nijmeijer
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  4. R Willemze
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  5. J H F Falkenburg
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Jedema, I., Barge, R., Nijmeijer, B. et al. Recruitment of leukemic cells from G0 phase of the cell cycle by interferons results in conversion of resistance to daunorubicin. Leukemia 17, 2049–2051 (2003). https://doi.org/10.1038/sj.leu.2403085

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