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Simultaneous occurrence of chronic myeloid leukemia and multiple myeloma: Evaluation by FISH analysis and in vitro expansion of bone marrow cells

Leukemia volume 17, pages 1426–1428 (2003)Cite this article

TO THE EDITOR

The simultaneous occurrence of CML and MM, an extremely rare event that has been reported in only five cases,1 raises the question of a common clonal origin. So far, no evidence has been obtained supporting such a hypothesis. In two of the reported cases the diseases occurred simultaneously,1,2 in one patient CML antedated MM,3 and in the other two CML developed after MM,4,5 but in none of the cases a common cellular origin was demonstrated. We here report on a patient with CML and MM whose malignant cell clones were characterized by cytogenetic and interphase fluorescence in situ hybridization (FISH) analysis and whose bone marrow (BM) cells were expanded in vitro to search for a common progenitor of CML and MM cells.

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Acknowledgements

Josef D Schwarzmeier and Medhat Shehata contributed equally to this work. We thank Professor VA Hoffbrand for critically reviewing this report. This study was partly supported by grants from the Austrian Science Foundation (Project #P15100), the ‘Jubilaeumsfonds’ of the Austrian National Bank (Grant #7760) and the ‘Medizinisch-Wissenschaftlicher Fonds des Buergermeisters der Bundeshauptstadt Wien’ (Project #1808).

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Authors and Affiliations

  1. Department of Hematology, Clinic of Internal Medicine I, University of Vienna, Austria

    J D Schwarzmeier, M Shehata & M Hilgarth

  2. L Boltzmann Institute for Cytokine Research, University of Vienna, Austria

    J D Schwarzmeier & M Shehata

  3. Department of Oncology, Clinic of Internal Medicine I, University of Vienna, Austria

    J Ackermann, H Kaufmann & J Drach

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  1. J D Schwarzmeier
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  2. M Shehata
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  3. J Ackermann
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  4. M Hilgarth
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  6. J Drach
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Schwarzmeier, J., Shehata, M., Ackermann, J. et al. Simultaneous occurrence of chronic myeloid leukemia and multiple myeloma: Evaluation by FISH analysis and in vitro expansion of bone marrow cells. Leukemia 17, 1426–1428 (2003). https://doi.org/10.1038/sj.leu.2402971

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