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Reply to letter from C Delfini et al

Leukemia volume 17, page 985 (2003)Cite this article

TO THE EDITOR

Delfini et al report additional indirect evidence that cytogenetic remissions of chronic myloid leukemia (CML) in response to interferon-α are associated with changes in immunoregulatory cell populations. The finding of concomitant upregulation of costimulatory molecules on antigen-presenting cells and expansion of CD8 cell populations is consistent with the hypothesis that interferon-α can induce clonal antigen-presenting cells to effectively present CML antigens, resulting in expansion of antileukemic cytotoxic T cells. In addition, cytogenetic remissions to interferon-α in CML have been shown to be associated with in vivo expansion of cytotoxic T lymphocytes specific for the myeloid-specific antigen proteinase 3.1, These insights into the mechanism of interferon-α activity will hopefully lead to the development of more specific immunotherapy for CML.

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References

  1. Moldrem JJ, Lee PP, Wang C, Felio K, Kantarjian HM, Champlin RE, Davis MM . Evidence that specific T-lymphocytes may participate in the elimination of chronic myelogenous leukemia. Nat Med 2000; 6: 1018–1023.

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  1. UCLA Division of Hematology/Oncology, 42-121 Centre for Health Sciences, 10833 Le Conte Avenue, Los Angeles, 90095 1678, CA, USA

    R L Paquette

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  1. R L Paquette
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Paquette, R. Reply to letter from C Delfini et al. Leukemia 17, 985 (2003). https://doi.org/10.1038/sj.leu.2402902

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