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MYC is not overexpressed in a case of chronic myelomonocytic leukemia with MYC-containing double minutes

Leukemia volume 17, pages 813–815 (2003)Cite this article

TO THE EDITOR

Double minutes (dmin) consist of circular acentric chromatin and are a cytogenetic manifestation of gene amplification, presumably providing the cell with a large number of copies of the target oncogene and resulting in growth advantage. They have been reported in a wide variety of neoplastic disorders, being particularly common in neuroblastomas and brain tumors.1 In hematologic malignancies, however, dmin are found in less than 1% of larger series of acute myeloid leukemias (AML), myelodysplastic syndromes (MDS), chronic myeloproliferative disorders, chronic myeloid leukemias, and acute lymphoblastic leukemias.1 In these diseases, dmin appear to be more frequent in myeloid malignancies, especially AML,1 and may be associated with a poor prognosis.2,3 Most cases display additional chromosomal aberrations; the few cases reported to date with dmin as a sole abnormality have, with one exception, all been AML.1

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Acknowledgements

This study was supported by grants from the Swedish Cancer Society.

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Authors and Affiliations

  1. Department of Clinical Genetics, Lund University Hospital, Sweden

    K Paulsson, C Lassen, T Fioretos & B Johansson

  2. Department of Hematology, Halmstad Hospital, Sweden

    N Kuric

  3. Department of Hematology, Lund University Hospital, Sweden

    R Billström

  4. Department of Molecular Cell Biology, Laboratory for Cytochemistry and Cytometry, Leiden University Medical Center, The Netherlands

    H J Tanke

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  1. K Paulsson
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Paulsson, K., Lassen, C., Kuric, N. et al. MYC is not overexpressed in a case of chronic myelomonocytic leukemia with MYC-containing double minutes. Leukemia 17, 813–815 (2003). https://doi.org/10.1038/sj.leu.2402841

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