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Acute Lymphoblastic Leukemia

Deletions on der(9) chromosome in adult Ph-positive acute lymphoblastic leukemia occur with a frequency similar to that observed in chronic myeloid leukemia

Leukemia volume 17, pages 528–531 (2003)Cite this article

Abstract

The t(9;22)(q34;q11), generating the Philadelphia chromosome (Ph), is found in more than 90% of patients with chronic myeloid leukemia (CML) and in 15–30% of adults with acute lymphoblastic leukemia (ALL). Different groups have recently described the presence of large genomic deletions adjacent to the translocation breakpoint on the derivative chromosome 9 in 9–16% of CML patients. In the present paper, we report a FISH study of 45 Ph+ adult ALL patients with the aim of investigating the presence of deletions on derivative chromosome 9. In four (9%) of 45 cases, all showing an M-bcr, we detected deletions on der(9). The frequency of deletions we observed is similar to that reported in CML patients. The association of an M-bcr breakpoint and deletions appears significant (P=0.03). Some authors have suggested a very low incidence of der(9) deletions in ALL. This discrepancy can be explained by taking into account the low percentage of M-bcr ALL patients in the latter study (18%) compared to the present one (44%).

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Acknowledgements

The financial support of Associazione Italiana per Ricerca contro il Cancro (AIRC), CEGBA, MIUR (Ministero Istruzione Università e Ricerca), CNR (Centro Nazionale della Ricerca), and FIRB-MIUR (Fondo Investimento Ricerca Biologica) is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Hematology, University of Bari, Italy

    G Specchia, F Albano, A Zagaria & V Liso

  2. Department of Hematology, University and Hospital of Foggia, Italy

    G Specchia & L Anelli

  3. Sezione di Genetica-DAPEG, University of Bari, Italy

    L Anelli, C T Storlazzi, A Zagaria & M Rocchi

  4. Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza of Rome, Italy

    M Mancini, R Foà & F Manolelli

  5. Institute of Hematology, University of Ferrara, Italy

    A Cuneo

  6. Dipartimento di Biochimica e Biotecnologie Mediche, CEINGE-Biotecnologie Avanzate, Universitá Federico II, Napoli, Italy

    F Pane

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  1. G Specchia
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  2. F Albano
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  3. L Anelli
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  4. C T Storlazzi
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  11. V Liso
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Specchia, G., Albano, F., Anelli, L. et al. Deletions on der(9) chromosome in adult Ph-positive acute lymphoblastic leukemia occur with a frequency similar to that observed in chronic myeloid leukemia. Leukemia 17, 528–531 (2003). https://doi.org/10.1038/sj.leu.2402829

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