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Engraftment of allogeneic mesenchymal stem cells in the bone marrow of a patient with severe idiopathic aplastic anemia improves stroma

Leukemia volume 17, pages 474–476 (2003)Cite this article

TO THE EDITOR

Bone marrow (BM) consists of the hematopoietic stem cell (HSC) compartment and the microenvironment which regulates hematopoiesis. Microenvironment is constituted by stromal cells, adipocytes and osteoblasts, all derived from the mesenchymal stem cells (MSC).1 Animal studies have indicated that MSC can engraft in BM.2 In humans a study on children with osteogenesis imperfecta receiving allogeneic MSC indicated the presence of donor cells on in vitro osteoblast culture albeit at a low level.3 MSC have also immuno suppressive properties and can induce tolerance.4 Although severe aplastic anemia (SAA) is an auto-immune disease where the stroma usually functions normally, damage of the microenvironment has been observed in a subset of SAA patients.5

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Authors and Affiliations

  1. Department of Hematology, hôpital Saint-Antoine, AP-HP, Paris, France

    L Fouillard, S Lesage, A Najman & N-C Gorin

  2. Laboratoire de recherche sur la thérapie cellulaire, LTCRA/UPRES EA1638, Université Paris VI (Pierre et Marie Curie), Association Claude Bernard et Institut de Protection et de Sureté Nucléaire (IPSN), Paris, France

    L Fouillard, M Bensidhoum, M Lopez, D Thierry, P Gourmelon & N-C Gorin

  3. Service d’hématologie biologique, hôpital Henri-Mondor, AP-HP, Créteil, France

    D Bories

  4. Laboratoire d’anatomo-pathologie, hôpital Saint-Antoine, AP-HP, Paris, France

    H Bonte

  5. Osiris Therapeutics, Baltimore, MD, USA

    A-M Moseley & A Smith

  6. EFS hôpital Henri-Mondor, AP-HP, Créteil, France

    F Beaujean

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  1. L Fouillard
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Fouillard, L., Bensidhoum, M., Bories, D. et al. Engraftment of allogeneic mesenchymal stem cells in the bone marrow of a patient with severe idiopathic aplastic anemia improves stroma. Leukemia 17, 474–476 (2003). https://doi.org/10.1038/sj.leu.2402786

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  • DOI: https://doi.org/10.1038/sj.leu.2402786

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