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Correlation of bone marrow angiogenesis and mast cells with tryptase activity in myelodysplastic syndromes

Leukemia volume 16, pages 1680–1684 (2002)Cite this article

Abstract

Bone marrow samples from 30 patients with myelodysplastic syndromes (MDS) grouped according to the International Prognostic Scoring System for MDS were investigated for counts of microvessels, total metachromatic mast cells (MC) and MC expressing tryptase, an angiogenesis-inducing molecule. Counts were higher in patients with a poor prognosis. The observation of a high correlation between microvessel counts and both total metachromatic and tryptase-reactive MC in all samples suggests that angiogenesis in MDS increases with their progression and that MC may intervene in the angiogenic response in MDS through tryptase contained in their secretory granules.

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Acknowledgements

This study was supported in part by grants from Associazione Italiana per la Ricerca sul Cancro, Milan, and Associazione Italiana per la Lotta al Neuroblastoma, Genoa, Italy.

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Authors and Affiliations

  1. Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy

    D Ribatti & B Nico

  2. Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy

    A Vacca & F Dammacco

  3. Institute of Pathology, University of Bari Medical School, Bari, Italy

    A Marzullo

  4. Ospedale Generale ‘F Miulli’, Acquaviva delle Fonti, Italy

    G Polimeno & G Lucarelli

  5. Department of Medical and Morphological Research, Section of Anatomy, University of Udine Medical School, Udine, Italy

    E Crivellato

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  1. D Ribatti
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Ribatti, D., Polimeno, G., Vacca, A. et al. Correlation of bone marrow angiogenesis and mast cells with tryptase activity in myelodysplastic syndromes. Leukemia 16, 1680–1684 (2002). https://doi.org/10.1038/sj.leu.2402586

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  • DOI: https://doi.org/10.1038/sj.leu.2402586

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