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Infrequent rearrangement of the STAT5b locus in primary human hematologic malignancies

Leukemia volume 16, pages 1568–1569 (2002)Cite this article

We have previously reported on an original gene fusion between STAT5b and the retinoic acid receptor alpha (RARα) in a patient with an acute promyelocytic leukemia-like phenotype (APL-L).1 A large number of transcription factors have been involved in the development and/or the progression of leukemia. The STAT (signal transducer and activator of transcription) family of transcription factors is composed of seven members in which STAT5 (a and b both mapped on 17q11.2) was shown to be activated by cytokines that regulate proliferation and differentiation in all hematopoietic lineages.2 Receptors without intrinsic tyrosine kinase activity are coupled with Jak proteins, a family of cytoplasmic tyrosine kinase. Activated Jak proteins phosphorylate the cytoplasmic tail of the receptor that serves as a docking site for STAT proteins. After tyrosine phosphorylation, STAT proteins dimerize, translocate to the nucleus and regulate expression of gene containing interferon responsive elements sequences in their promoters.

To date, four chromosomal rearrangements have been described in APL that juxtapose the RARα coding region to PML (promyelocytic leukemia), PLZF (promyelocytic leukemia zinc finger), NPM (nucleophosmin) and NuMA (nuclear mitotic apparatus).3 The STAT5b-RARα gene fusion is the first structural STAT gene rearrangement associated with a human tumor.

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Acknowledgements

The authors thank WJ Leonard (Bethesda, MD, USA) for the STATb cDNA. This study was supported by la Ligue Nationale Contre le Cancer, and Foundation contre la Leucémie. NT was supported by a fellowship from le comité Lorraine de la Ligue Nationale contre le cancer.

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Authors and Affiliations

  1. Laboratoire de Génétic Médicale, EA 3441, CHU Nancy-Brabois, France

    N Touche, C Philippe, M-J Gregoire, C Arnould, M Franck & P Jonveaux

  2. Laboratoire de Cytogénétique Hématologique, CHU Toulouse-Purpan, France

    N Dastugue

  3. Laboratoire de Cytogénétique, CHU, Dijon, France

    F Mugneret

  4. Laboratoire de Cytogénétique, Institut Paoli Calmette, Marseille, France

    M Lafage-Pochitaloff

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  1. N Touche
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Touche, N., Philippe, C., Gregoire, MJ. et al. Infrequent rearrangement of the STAT5b locus in primary human hematologic malignancies. Leukemia 16, 1568–1569 (2002). https://doi.org/10.1038/sj.leu.2402542

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