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Prognostic variables in newly diagnosed children and adolescents with acute myeloid leukemia: Children's Cancer Group Study 213

Leukemia volume 16, pages 601–607 (2002)Cite this article

Abstract

The objective of this study was to identify biologic parameters that were associated with either exceptionally good or poor outcome in childhood acute myeloid leukemia (AML). Among the children with AML who entered Children's Cancer Group trial 213, 498 patients without Down syndrome or acute promyelocytic leukemia (APL) comprise the basis for this report. Univariate comparisons of the proportion of patients attaining complete remission after induction (CR) indicate that, at diagnosis, male gender, low platelet count (⩽20 000/μl), hepatomegaly, myelodysplastic syndrome (MDS), French–American– British (FAB) category M5, high (>15%) bone marrow (BM) blasts on day 14 of the first course of induction, and +8 are associated with lower CR rates, while abnormal 16 is associated with a higher CR rate. Multivariate analysis suggests high platelet count at diagnosis (>20 000/μl), absence of hepatomegaly, ⩽15% day 14 BM blast percentage, and abnormal 16 are independent prognostic factors associated with better CR. Univariate analysis demonstrated a significant favorable relationship between platelet count at diagnosis (>20 000/μl), absence of hepatomegaly, low percentage of BM blasts (⩽15%), and abnormal 16 with overall survival. Absence of hepatomegaly, ⩽15% day 14 BM blast percentage, and abnormal 16 were determined to be independent prognostic factors associated with better survival.

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Acknowledgements

Contributing Children's Cancer Group investigators, institutions and grant numbers are given in the appendix. Grant support from the Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Department of Health and Human Services.

Table 5 Appendix: Participating principal investigators – children's cancer group
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Authors and Affiliations

  1. Children's Hospital Research Foundation, University of Cincinnati Medical Center, Cincinnati, OH, USA

    RJ Wells & BC Lampkin

  2. Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA

    DC Arthur

  3. University of Cincinnati Medical Center, Cincinnati, OH, USA

    A Srivastava

  4. Parker Hughes Institute, St Paul, MN, USA

    NA Heerema

  5. University of Chicago, Chicago, IL, USA

    M Le Beau

  6. South Carolina Cancer Center, University of South Carolina, Columbia, SC, USA

    WG Woods

  7. Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    TA Alonzo, WB Howells, JD Buckley & T Tjoa

  8. Children's Hospital Medical Center, Seattle, WA, USA

    DR Benjamin

  9. Mayo Medical Center, Rochester, MN, USA

    DL Betcher & WA Smithson

  10. University of California Los Angeles, Los Angeles, CA, USA

    SA Feig

  11. Virginia Piper Cancer Institute, Abbot Northwestern Hospital, Minneapolis, MN, USA

    T Kim

  12. Children's Hospital and University of Colorado Cancer Center, Denver, CO, USA

    LF Odom

  13. Children's Hospital of Columbus and Ohio State University, Columbus, OH, USA

    FB Ruymann

  14. University of Iowa, Iowa City, IA, USA

    R Tannous

  15. University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    JK Whitt

  16. Doernbecher Children's Hospital, The Oregon Health Sciences University, Portland, OR, USA

    L Wolff

  17. Children's Oncology Group Operations Center, Arcadia, CA, USA

    AB Buxton

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  1. RJ Wells
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  2. DC Arthur
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  3. A Srivastava
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Wells, R., Arthur, D., Srivastava, A. et al. Prognostic variables in newly diagnosed children and adolescents with acute myeloid leukemia: Children's Cancer Group Study 213. Leukemia 16, 601–607 (2002). https://doi.org/10.1038/sj.leu.2402390

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