Abstract
Transplantation with histocompatible identical siblings is a curative treatment for patients with myelodysplastic syndromes (MDS). Alternative treatments, such as transplantation with other family donors, are an option for patients without HLA-identical siblings. This study evaluated transplantation with genotypically nonidentical family donors and compared the results to those obtained with unrelated donors and autologous stem cell transplantation. Overall 3-year survival was 35% for the 79 patients transplanted using genotypically nonidentical donors, DFS was 31%, relapse risk 16%, and the treatment-related mortality (TRM) 62%. Patients transplanted using phenotypically identical family donors had a significantly superior survival and a lower TRM than patients transplanted with mismatched family donors. Age had no influence on the outcome of transplantation. The DFS of patients transplanted in early stage of the disease was 42% compared to 28% in patients transplanted with more advanced disease (P = 0.03). The results of transplantation with mismatched family donors were comparable to those obtained with unrelated donor transplantation. This suggests that nonidentical family donors may be considered if a fully matched unrelated donor is not available. The TRM of patients transplanted with nonidentical family donors is significantly higher than the TRM of patients transplanted with autologous stem cells. The disease-free survival of ASCT is not inferior to allogeneic transplantation using nonidentical family donors, and the intensity of the treatment is much lower. The choice of ASCT or alternative donor transplantation must be influenced by the age of the patient and the risk of relapse. For patients under the age of 20 years the treatment of choice may indeed be an alternative donor transplantation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Lowenthal RM, Marsden KA . Myelodysplastic syndromes Int J Hematol 1997 65: 319–338
Bennett JM, Catovsky D, Daniel MD, Flandrin G, Galton DAG, Gralnick HR, Sultan C (FAB Co-operative Group) . Proposals for the classification of the myelodysplastic syndromes Br J Haematol 1982 51: 189–199
Farrow A, Jacobs A, West RR . Myelodysplasia, chemical exposure and other environmental factors Leukemia 1989 3: 33–35
Goldberg H, Lusk E, More J . Survey of exposure to genotoxic agents in primary myelodysplastic syndrome. Correlation with chromosome patterns and data on patients without hematological disease Cancer Res 1990 50: 6876–6881
Third MIC Cooperative Study Group . Recommendations for a morphologic, immunologic and cytogenetic (MIC) working classification of primary and therapy-related myelodysplastic disorders Cancer Genet Cytogenet 1988 32: 1–10
Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, Sanz M, Vallespi T, Hamblin T, Oscier D, Ohyashiki K, Toyama K, Aul C, Mufti G, Bennett J . International Scoring System for Evaluating Prognosis in Myelodysplastic Syndromes Blood 1997 89: 2079–2088
Aul C, Gatterman N, Schneider W . Age-related incidence and other epidemiological aspects of myelodysplastic syndromes Br J Haematol 1992 82: 358–367
De Witte T de . New treatments approaches for myelodysplastic syndrome and secondary leukemia's Ann Oncol 1994 5: 401–408
De Witte T, van Biezen A, Hermans J, Labopin M, Runde V, Or R, Meloni G, Brunet Mauri S, Carella A, Apperley J, Gratwohl A, Laporte J-P . Autologous bone marrow transplantation for patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia following MDS Blood 1997 90: 3853–3857
De Witte T . Stem cell transplantation for patients with myelodysplastic syndrome and secondary leukemias Int J Hematol 2000 72: 151–156
Runde V, de Witte T, Arnold R, Gratwohl A, Hermans J, Van Biezen A, Niederwieser D, Labopin M, Walter-Noel MP, Bacigalupo A, Jacobsen N, Ljungman P, Carreras E, Kolb HJ, Aul C, Apperley J . Bone marrow transplantation from HLA-identical siblings as first-line treatment in patients with myelodysplastic syndromes: early transplantation has improved outcome Bone Marrow Transplant 1998 21: 255–261
Appelbaum FR, Barrall J, Storb R, Fisher LD, Schoch G, Ramberg RE, Shulman H, Anasetti C, Bearman SJ, Beatty P, Bensinger WJ, Buckner CD, Clift RA, Hansen JA, Martin P, Petersen FB, Sanders JE, Singer J, Stewart P, Sullivan KM, Witherspoon RP, Thomas ED . Bone marrow transplantation for patients with myelodysplasia Ann Int Med 1990 112: 590–599
Anderson JE, Anasetti E, Appelbaum FR, Schoch G, Gooley TA, Hansen JA, Buckner D, Sanders JE, Sullivan KM, Storb R . Unrelated donor transplantation for myelodysplasia (MDS) and MDS-related acute myeloid leukemia Br J Haematol 1996 93: 59–67
De Witte T, Hermans J, Vossen J, Bacigalupo A, Meloni G, Jacobsen N, Ruutu T, Ljungman P, Gratwohl A, Runde V, Niederwieser D, Van Biezen J, Devergie A, Cornelissen J, Jouet J-P, Arnold R, Apperley J . Haematopoietic stem cell transplantation for patients with myelodysplastic syndromes and secondary leukaemias: a report on behalf of the Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation Br J Haematol 2000 110: 620–630
De Witte T, Suciu S, Peetermans M, Fenaux P, Strijckmans P, Hayat M, Jaksic B, Selleslag D, Zittoun R, Dardenne M, Solbu G, Zwierzina H, Muus P . Intensive chemotherapy for poor prognosis myelodysplasia (MDS) and secondary acute myelogenous leukemia following MDS of more than 6 months duration. A pilot study by the Leukemia Cooperative Group of the European Organisation for Research and Treatment in Cancer. (EORTC-LCG) Leukemia 1995 9: 1805–1810
Aivado M, Rong A, Germing U, Gatterman N, Kobbe G, Rieth C, Haas R, Aul C . Long-term remission after intensive chemotherapy in advanced myelodysplastic syndromes is generally associated with restoration of polyclonal haemopoiesis Br J Haematol 2000 110: 884–886
Delforge M, Demuynck H, Vandenberghe P, Verhoef G, Zachee P, Duppen VV, Marijnen P, Van den Berghe H, Boogaerts MA . Polyclonal primitive hematopoietic progenitors can be detected in mobilized peripheral blood from patients with high-risk myelodysplastic syndromes Blood 1995 86: 3660–3667
Demuynck H, Delforge G, Verhoef P, Zachee P, Vandenberghe P, Van den Berghe H, Boogaerts M . Feasibility of peripheral blood progenitor cell harvest and transplantation in patients with poor-risk myelodysplastic syndromes Br J Haematol 1996 92: 351–359
Carella AM, Delana A, Lerma E, Podesta M, Benvenuto F, Chimirri F, Sessarego M, Prencipe E, Frassoni F . In vivo mobilization of karyotypically normal peripheral blood progenitor cells in high-risk MDS, secondary or therapy-related acute myelogenous leukemia Br J Haematol 1996 95: 127–130
Laporte JP, Isnard F, Lesage S, Fenaux P, Douay L, Lopez M, Stacowiak J, Najman A, Gorin NC . Autologous bone marrow transplantation with marrow purged by mafosfamide in seven patients with myelodysplastic syndromes in transformation (AML-MDS): a pilot study Leukemia 1993 7: 2030–2033
Schiller G, Lee M, Paquette R, Sawyers C, Khoubian F, Territo M . Transplantation of autologous peripheral blood progenitor cells procured after high-dose cytarabine-based consolidation chemotherapy for adults with secondary acute myelogenous leukemia in first remission Leuk Lymphoma 1999 33: 475–484
Wattel E, Solary E, Leleu X, Dreyfus F, Brion A, Jouet JP, Hoang-Ngoc C, Maloisel F, Guerci A, Rochant H, Gratecos N, Casassus P, Janvier M, Leypelley P, Fenaux P . A prospective study of autologous bone marrow or peripheral blood stem cell transplantation after intensive chemotherapy in myelodysplastic syndromes Leukemia 1999 13: 524–529
Arnold R, De Witte T, Van Biezen A, Hermans J, Jacobsen N, Runde V, Gratwohl A, Apperley JF . Unrelated bone marrow transplantation in patients with myelodysplastic syndromes and secondary acute myeloid leukemia: an EBMT survey Bone Marrow Transplant 1998 21: 1213–1216
Kernan NA, Bartsch G, Ash RC, Beatty PG, Champlin R, Filipovich A, Gajewski J, Hansen JA, Henslee-Downey J, McCullough J, McGlave P, Perkins HA, Phillips GL, Sanders J, Stroncek D, Thomas ED, Blume K . Analysis of 462 transplantations from unrelated donors facilitated by the National marrow Donor Program N Engl J Med 1993 328: 593–602
Author information
Authors and Affiliations
Consortia
Rights and permissions
About this article
Cite this article
de Witte, T., Pikkemaat, F., Hermans, J. et al. Genotypically nonidentical related donors for transplantation of patients with myelodysplastic syndromes: comparison with unrelated donor transplantation and autologous stem cell transplantation. Leukemia 15, 1878–1884 (2001). https://doi.org/10.1038/sj.leu.2402296
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.leu.2402296
Keywords
This article is cited by
-
Myeloablative conditioning regimens with combined of haploidentical and cord blood transplantation for myelodysplastic syndrome patients
Bone Marrow Transplantation (2018)
-
Haploidentical transplant for myelodysplastic syndrome: registry-based comparison with identical sibling transplant
Leukemia (2016)
-
Unrelated cord blood transplantation after myeloablative conditioning in adults with advanced myelodysplastic syndromes
Bone Marrow Transplantation (2011)
-
Analysis of risk factors influencing outcome in children with myelodysplastic syndrome after unrelated cord blood transplantation
Leukemia (2011)
-
Allogeneic hematopoietic cell transplantation for myelodysplastic syndrome: prognostic significance of pre-transplant IPSS score and comorbidity
Bone Marrow Transplantation (2010)