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Minimally differentiated acute myeloid leukemia (AML-M0) with lymphoid presentation at relapse: a case report

Leukemia volume 15, pages 1673–1674 (2001)Cite this article

Recently, Iwata et al 1 reported a case of T-ALL misdiagnosed as AML-M0, thus pointing out the limitations of the diagnostic criteria for this immature leukemia. The FAB cooperative group defined guidelines in 1991: AML-M0 diagnosis require negative myeloperoxidase (MPO) and Sudan Black B (SBB) staining, positive myeloid markers (usually CD13 and 33, but also CD14, CD15, CD11b) and negative T and B associated markers.2 Since then, many authors shaped these guidelines into a new definition, in which some lymphoid antigens were not considered as exclusion criteria anymore, albeit negativity for cytoplasmic CD3 (cCD3), cCD22 and CD79a remains compulsary to avoid misdiagnosis with biphenotypic acute leukemia. This immunological classification of AML-M0 was supported by the proposition of the EGIL.3

Nevertheless, AML-M0 is heterogenous with respect to immunophenotyping and cytogenetics and we are still lacking a specific marker to single out this sybtype as an entity distinct from the other immature leukemias.

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References

  1. Iwata H, Kami M, Kishi Y, Oki Y et al. Limitations of the diagnostic criteria for minimally differentiated acute myeloid leukemia (AML-M0) Leukemia 2000 14: 2013–2014

    Article  CAS  Google Scholar 

  2. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C . Proposal for the recognition of minimally differentiated acute myeloid leukemia (AML-M0) Br J Haematol 1991 78: 325–329

    Article  CAS  Google Scholar 

  3. European Group for the Immunological Characterization of Leukemia (EGIL) . Proposals for the immunological classification of acute leukemias Leukemia 1995 9: 1783–1786

    Google Scholar 

  4. Venditti A, Del Poeta G, Buccisano F, Tamburini A, Cox MC, Stasi R, Bruno A, Aronica G, Maffei L, Suppo G, Simone MD, Forte L, Cordero V, Postorino M, Tuffili V, Isacchi G, Masi M, Papa G, Amadori S . Minimally differentiated acute myeloid leukemia (AML-M0): comparison of 25 cases with other French–American–British subtypes Blood 1997 89: 621–629

    CAS  PubMed  Google Scholar 

  5. Betz SA, Foucar K, Head DR, Chen IM, Willman CI . False-positive flow cytometric platelet glycoprotein IIb/IIIa expression in myeloid leukemias secondary to platelet adherence to blasts Blood 1992 79: 2399–2403

    CAS  PubMed  Google Scholar 

  6. Kotylo PK, Seo IS, Smith FO, Heerema NA, Fineberg NS, Miller K, Greene ME, Chou P, Orazi A . Flow cytometric immunophenotypic characterization of pediatric and adult minimally differentiated acute myeloid leukemia (AML-M0) Am J Clin Pathol 2000 113: 193–200

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Service d'Hématologie Biologique, CHU Bocage, Dijon, France

    L Ysebaert, PM Carli, F Girodon & M Maynadié

  2. Service d'Hématologie Clinique, CHU Bocage, Dijon, France

    RO Casasnovas & D Caillot

  3. Laboratoire de Cytogénetique, CHU Bocage, Dijon, France

    F Mugneret

Authors
  1. L Ysebaert
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  2. PM Carli
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  3. RO Casasnovas
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  7. M Maynadié
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Ysebaert, L., Carli, P., Casasnovas, R. et al. Minimally differentiated acute myeloid leukemia (AML-M0) with lymphoid presentation at relapse: a case report. Leukemia 15, 1673–1674 (2001). https://doi.org/10.1038/sj.leu.2402240

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