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Three further cases of t(8;14)(q11.2;q32) in acute lymphoblastic leukemia

Leukemia volume 15, pages 1304–1305 (2001)Cite this article

We read with interest the article by Kaleem et al1 reviewing 21 cases of acute lymphoblastic leukemia (ALL) with the rare chromosomal translocation, t(8;14)(q11.2;q32), and wish to inform readers of a further three cases.

The three new patients were identified through the Leukaemia Research Fund/UK Cancer Cytogenetics Group Karyotype Database in Acute Lymphoblastic Leukaemia (Database), which is responsible for co-ordinating the cytogenetic results of patients submitted to the UK treatment trials for ALL. Patient 1 was entered to the current childhood trial, ALL97; patient 2 to the current adult trial, UKALLXII and patient 3 to the previous adult trial, UKALLX. Cytogenetic analysis was carried out on diagnostic bone marrow samples in the local UK cytogenetics laboratories. Slide review and fluorescence in situ hybridization (FISH) studies were carried out at the Database.

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References

  1. Kaleem Z, Shuster JJ, Carroll AJ, Borowitz MJ, Pullen DJ, Camitta BM, Zutter MM, Watson MS . Acute lymphoblastic leukemia with an unusual t(8;14)(q11.2;q32): a Pediatric Oncology Group study Leukemia 2000 14: 238–240

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Acknowledgements

We would like to thank the Leukaemia Research Fund for their financial support and the Childhood and Adult Leukaemia Working Parties.

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Authors and Affiliations

  1. Department of Haematology, Leukaemia Research Fund/UK Cancer Cytogenetics Group Karyotype Database in Acute Lymphoblastic Leukaemia, Royal Free and University College Medical School, London, UK

    S-A Byatt, K-L Cheung, H Mazzullo, M Martineau, C Bennett, K Roberts, L Harewood, N Sumption & CJ Harrison

  2. Department of Medical Oncology, Imperial Cancer Research Fund, St Bartholomew's Hospital, London, UK

    DM Lillington

  3. Regional Genetics Centre, Belfast City Hospital, Belfast, UK

    M Humphreys

  4. Clinical Trials Service Unit, Radcliffe Infirmary, Oxford, UK

    J Burrett

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  1. S-A Byatt
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  2. K-L Cheung
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  3. DM Lillington
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Byatt, SA., Cheung, KL., Lillington, D. et al. Three further cases of t(8;14)(q11.2;q32) in acute lymphoblastic leukemia. Leukemia 15, 1304–1305 (2001). https://doi.org/10.1038/sj.leu.2402166

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  • DOI: https://doi.org/10.1038/sj.leu.2402166

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