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Deletion of the multidrug resistance protein 1 (MRP1) gene in acute myeloid leukemia patients with inversion 16: expression of MRP1 homologues

Leukemia volume 15, pages 191–192 (2001)Cite this article

In the prospective study of Döhner et al,1 it is described that the deletion of the multidrug resistance protein (MRP1) gene has no prognostic impact in acute myeloid leukemia (AML) patients with an inversion on chromosome 16. These findings are in agreement with the results we recently described,2 and might be due to the fact that the expression of MRP1 homologues can be upregulated in the case of MRP1 deletion.

MRP1, encoded by the MRP1 gene located on chromosome 16p13, is a member of the superfamily of ATP-binding cassette (ABC) transporters. MRP1 has been shown to transport a broad range of organic substrates, and the expression of MRP1 results in resistance to different classes of chemotherapeutic agents. The MRP family of proteins consists of at least six family members, MRP1 to MRP6.3 However, the role of the MRP1 isoforms is not yet well defined. MRP2, MRP3 and MRP5 have been described to transport chemotherapeutic agents, such as cisplatin, doxorubicin, etoposide and 6-mercaptopurine, but less is known about the transport mechanisms of the proteins MRP4 and MRP6. Another membrane transporter, P-glycoprotein (P-gp) encoded by the MDR1 gene, has also been shown to transport chemotherapeutic drugs. The simultaneous expression and function of both proteins has been shown to be correlated with poor overall survival in AML.4

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References

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Authors and Affiliations

  1. Division of Haematology, University Hospital of Groningen, Groningen, The Netherlands

    DM van der Kolk & E Vellenga

  2. Division of Medical Oncology, University Hospital of Groningen, Groningen, The Netherlands

    DM van der Kolk & EGE de Vries

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  1. DM van der Kolk
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  2. EGE de Vries
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  3. E Vellenga
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van der Kolk, D., de Vries, E. & Vellenga, E. Deletion of the multidrug resistance protein 1 (MRP1) gene in acute myeloid leukemia patients with inversion 16: expression of MRP1 homologues. Leukemia 15, 191–192 (2001). https://doi.org/10.1038/sj.leu.2401949

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