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Characteristics and analysis of normal and leukemic stem cells: current concepts and future directions

Leukemia volume 14, pages 1711–1717 (2000)Cite this article

Abstract

Acute myeloid leukemias (AML) are considered to be clonal disorders involving early hematopoietic progenitor cells. The recent advances in characterization of early stem cells give rise to the question whether it is possible to distinguish healthy progenitors from cells of the leukemic clone in leukemia patients. Differences and similarities in phenotype, genotype and biology are described for leukemic cells and normal hematological progenitors. Recent new insights into human stem cell development offer the perspective that distinction between benign and malignant progenitors might be possible in the future at a very early stage of maturation.

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Acknowledgements

This work was supported in part by grants of the Deutsche Forschungsgemeinschaft (Ne 310/6–3), and the José Carreras Stiftung.

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  1. Department of Hematology/Oncology/Immunology at the Universitätsklinikum of the Philipps-Universität Marburg, Baldingerstrasse, Marburg, 35043, Germany

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Brendel, C., Neubauer, A. Characteristics and analysis of normal and leukemic stem cells: current concepts and future directions. Leukemia 14, 1711–1717 (2000). https://doi.org/10.1038/sj.leu.2401907

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