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Allelic losses and genetic instabilities of PTEN and p73 in non-Hodgkin lymphomas

Leukemia volume 14, pages 1325–1327 (2000)Cite this article

Disruption of oncogenes and inactivation of tumor suppressor genes plays a central role in the pathogenesis of malignant disease. In leukemias and lymphomas, the detailed characterization of such abnormalities has provided a basis for disease classification, and has helped to define prognosis in individual patients. With regard to non-Hodgkin's lymphomas, little is known about the involvement of tumor suppressor genes with the exception of p53, and p16/INK4a/ARF, which are altered in a fraction of tumors during the most advanced disease stages (see Refs in Herranz et al1).

Two novel tumor suppressor genes (PTEN and p73) have been recently identified, which could be the target of inactivation in NHLs. PTEN is mutated or homozygously deleted in many different human tumors,23 but only in a small percentage of primary lymphoid malignancies (see Refs in Siebert et al4). P73 is a new member of the p53 family that is frequently deleted in neuroblastoma and other human cancers.5 Interestingly, transcriptional silencing of this gene in lymphoid malignancies due to hypermethylation of its 5′ CpG island has been recently reported.6 However, allelic losses were not detected in the cell lines exhibiting lack expression of this gene.

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Acknowledgements

This work was supported by grants from the Comunidad Autónoma de Madrid (08/0009/1997; 081/0043.2/98) and the Fundación Ramón Areces.

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Authors and Affiliations

  1. Departmento de Biologia, Laboratorio de Genética Molecular Humana, Universidad Autónoma de Madrid, Madrid, Spain

    M Herranz, J Santos & J Fernández-Piqueras

  2. Deparmentos de Genética y Pathologia, Fundación Jiménez Diaz, Madrid, Spain

    M Urioste, JB Martinez-Delgado, C Rivas & J Benitez

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  1. M Herranz
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Herranz, M., Urioste, M., Santos, J. et al. Allelic losses and genetic instabilities of PTEN and p73 in non-Hodgkin lymphomas. Leukemia 14, 1325–1327 (2000). https://doi.org/10.1038/sj.leu.2401813

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