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Jumping Translocations

Jumping translocation in acute leukemia of myelomonocytic lineage: a case report and review of the literature

Leukemia volume 14, pages 119–122 (2000)Cite this article

Abstract

Jumping translocation (JT) is a very rare cytogenetic event, occurring especially in cancer. We describe a case of secondary acute monocytic leukemia (AML5b) with a JT involving the 3q13-3qter segment and leading to a partial trisomy 3. Each clone with JT was associated with trisomy 8 or tetrasomy 8. The literature of JT in AML cases is reviewed: only 13 cases of AML associated with JT have been previously described, seven of which are AML4/5 FAB subtype. Jumping translocation involvement in leukemogenesis is discussed.

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Authors and Affiliations

  1. Service d'Hématologie Clinique, CHU de Rennes, France

    M Bernard, PY Prise & T Lamy

  2. Laboratoire de Génétique et Biologie Cellulaire, CHU de Rennes, France

    F Lemée & F Picard

  3. Unité d'Hématologie, Clinique de Cesson-Sevigné, CHU de Rennes, France

    C Ghandour

  4. Laboratoire d'Hématologie, CHU de Rennes, France

    B Drenou

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  1. M Bernard
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Bernard, M., Lemée, F., Picard, F. et al. Jumping translocation in acute leukemia of myelomonocytic lineage: a case report and review of the literature. Leukemia 14, 119–122 (2000). https://doi.org/10.1038/sj.leu.2401637

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