Abstract
The TEL gene is involved in several chromosomal abnormalities of human hematopoietic malignancies. The chromosome 12 breakpoints frequently lie within the fifth intron of the gene, particularly in the most frequent translocation involving TEL, the t(12;21)(p13;q22). In order to search for a peculiar mechanism involved in the genesis of these translocations, we have established the sequence of two t(12;21) and a t(9;12)(q24;p13) breakpoints. Our data do not reveal the involvement of VDJ recombinase activity or Alu sequences but favor the occurrence of staggered breaks and DNA repair activity in the genesis of these translocations.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Romana, S., Poirel, H., Della Valle, V. et al. Molecular analysis of chromosomal breakpoints in three examples of chromosomal translocation involving the TEL gene. Leukemia 13, 1754–1759 (1999). https://doi.org/10.1038/sj.leu.2401564
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.leu.2401564
Keywords
This article is cited by
-
Frequency of ETV6/AML1 fusion in adult acute lymphoblastic leukemia
Leukemia (2003)
-
Molecular characterization of genomic AML1-ETO fusions in childhood leukemia
Leukemia (2001)
-
Breakpoint analysis by fluorescence in situ hybridization in myelodysplastic syndromes with t(3;12)(q26;p13) and expression of EVI1
Leukemia (2000)
