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Non-Hodgkin’s lymphomas and myeloid disorders: deletions associated with t(2;5) and t(3;5) detected by FISH

Leukemia volume 12, pages 1159–1162 (1998)Cite this article

Abstract

The nucleophosmin (NPM) gene is involved in two recurrent translocations in hematological malignancies: t(2;5) (p23;q35) in anaplastic large cell lymphoma (ALCL) and t(3;5)(q25.1;q34–35) in myelodysplasia and acute non-lymphocytic leukemia (ANLL). Using eight YACs encompassing the 5q34-q35 region, we could easily detect these two translocations. In both types of translocation, probable unexpected deletions were also discovered downstream of the breakpoint at 5q35.

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Authors and Affiliations

  1. URA 1967 CNRS, Laboratoire de Cytogénétique et de Génétique Oncologiques, France

    M-A Dragon-Durey, A-F Goguel, D Fauvet & A Bernheim

  2. Laboratoire de Cytogénétique, CHU Kremlin-Bicêtre, France

    C Leonard

  3. U 301 INSERM and SD 401 No. 301 CNRS IGM, Paris, France

    R Berger

  4. Unité des Marqueurs Génétiques des Cancers, Institut Gustave Roussy, Villejuif, France

    B Bressac-de-Paillerets

Authors
  1. M-A Dragon-Durey
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  2. A-F Goguel
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  3. C Leonard
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  4. R Berger
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  5. B Bressac-de-Paillerets
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  6. D Fauvet
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  7. A Bernheim
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Dragon-Durey, MA., Goguel, AF., Leonard, C. et al. Non-Hodgkin’s lymphomas and myeloid disorders: deletions associated with t(2;5) and t(3;5) detected by FISH. Leukemia 12, 1159–1162 (1998). https://doi.org/10.1038/sj.leu.2401047

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  • DOI: https://doi.org/10.1038/sj.leu.2401047

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