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Sensitivity: Resistance to Therapy and Apoptosis

Cell cycle arrest and apoptosis of leukemia cells induced by L-asparaginase

Leukemia volume 11, pages 1858–1861 (1997)Cite this article

Abstract

Apoptotic cell death of murine leukemia cells induced by E. coli L-asparaginase was studied. Deprivation of L-asparagine from the culture of L5178Y cells by L-asparaginase caused the fragmentation of chromosomal DNA of the leukemia cells within 24 h. Prior to the degradation of DNA, cell cycles of L5178Y cells were found to be arrested in G1 phase, and evidence of the DNA strand breaks was initially observed in G1 phase cells as early as 8 h after the asparaginase treatment. Therefore, apoptosis of leukemia cells induced by L-asparaginase is an event that is associated with the cell cycle arrest in G1 phase.

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Affiliations

  1. Department of Materials Science and Technology, Toin Human Science and Technology Center, Toin University of Yokohama, Yokohama, Japan

    T Ueno, K Ohtawa, K Mitsui, Y Kodera, M Hiroto, A Matsushima, Y Inada & H Nishimura

  2. CREST, Japan Science and Technology Corporation (JST), Saitama, Japan

    K Mitsui & H Nishimura

Authors
  1. T Ueno
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  2. K Ohtawa
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  3. K Mitsui
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  4. Y Kodera
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  5. M Hiroto
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  6. A Matsushima
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  7. Y Inada
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  8. H Nishimura
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Ueno, T., Ohtawa, K., Mitsui, K. et al. Cell cycle arrest and apoptosis of leukemia cells induced by L-asparaginase. Leukemia 11, 1858–1861 (1997). https://doi.org/10.1038/sj.leu.2400834

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  • DOI: https://doi.org/10.1038/sj.leu.2400834

Keywords

  • L-asparaginase
  • apoptosis
  • cell cycle
  • G1 arrest
  • leukemia

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