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Evidence for the embryonic origin of partial chromosome 7 deletion in monozygotic twins with juvenile chronic myelogenous leukemia

Leukemia volume 11, pages 306–310 (1997)Cite this article

Abstract

During donor evaluation for allogeneic bone marrow transplantation (BMT) of a 28-month-old child with juvenile chronic myelogeneous leukemia (JCML) with 46,XY,−7,+mar karyotype, the potential donor twin brother was found to be thrombocytopenic. Subsequent genotype analysis determined monozygosity with 98% probability. Bone marrow analysis of the twin brother revealed the same 46,XY,−7,+mar karyotype and a diagnosis of JCML was made. Metaphase FISH studies documented that mar chromosome in both twins contains the pericentromeric region of chromosome 7 and thus both twins had a partial monosomy of chromosome 7. A possible embryonic origin of del(7) is proposed.

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Authors and Affiliations

  1. Division of Hematology, Department of Medicine, Tumor Cytogenetics Laboratory and The Bone Marrow Transplantation Service, Mount Sinai School of Medicine, New York, USA

    V Najfeld, W Burnett, A Scalise & S Fruchtman

  2. Division of Hematology/Oncology, Department of Pediatrics, Mount Sinai School of Medicine, New York, USA

    A Vlachos

  3. Department of Pediatrics, Hematology-Oncology, Children’s Medical Center, State University of New York at Stony Brook, New York, USA

    R Parker

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  1. V Najfeld
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  2. A Vlachos
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  3. R Parker
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  4. W Burnett
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  5. A Scalise
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  6. S Fruchtman
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Najfeld, V., Vlachos, A., Parker, R. et al. Evidence for the embryonic origin of partial chromosome 7 deletion in monozygotic twins with juvenile chronic myelogenous leukemia. Leukemia 11, 306–310 (1997). https://doi.org/10.1038/sj.leu.2400565

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  • DOI: https://doi.org/10.1038/sj.leu.2400565

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