Abstract
This simple theory provides a function for non-histone proteins and an explanation for the large size of eukaryotic genomes, repetitive sequences in DNA, HnRNA and “processing” of nuclear RNA.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
McClintock, B., Brookhaven Symp. Quant. Biol., 18, 162 (1965).
Haldane, J. B. S., J. Genet., 55, 511 (1957).
Müller, H. J., Heritage from Mendel (edit. by Brink, R. A.), 419 (University of Wisconsin Press, Madison, 1967).
Ohno, S., Nature, 234, 134 (1971).
Britten, R. J., and Kohne, D. E., Science, 161, 629 (1968).
Johns, E. W., Ciba Symposium on Homeostatic Regulators (edit. by Wolstenholme, G. E. W., and Knight, J.), 128 (Churchill, London, 1969).
Paul, J., Symp. Soc. Exp. Biol. No. XXV: Control Mechanisms of Growth and Differentiation (edit. by Davies, D. D., and Balls, M.), 117 (Cambridge University Press, 1971).
Judd, B., Shen, M., and Kaufman, T., Genetics (in the press).
DuPraw, E. J., and Rae, P. M. M., Nature, 212, 598 (1966).
Berendes, H. D., and Beermann, W., Handbook of Molecular Cytology (edit. by Lima-de-Faria, A.), 501 (North Holland, Amsterdam, 1969).
Callan, H. G., Handbook of Molecular Cytology (edit. by Lima-de-Faria, A.), 541 (North Holland, Amsterdam, 1969).
Caspersson, T., Zech, I., Johansson, C., and Modest, E., Chromosoma, 30, 215 (1970).
Crick, F. H., Nature, 234, 25 (1971).
Paul, J., and Gilmour, R. S., J. Mol. Biol., 34, 305 (1968).
Mazia, D., Hayashi, T., and Yudovitch, K., Cold Spring Harbor Symp. Quant. Biol., 12, 122 (1947).
Bram, S., J. Mol. Biol., 58, 277 (1971).
Thomas, jun., C. A., Hamkalo, B. A., Misra, D. N., and Lee, C. S., J. Mol. Biol., 51, 621 (1970).
Miller, O. L., and Beatty, B. R., Science, 164, 955 (1969).
Brown, D. D., Wensink, P. C., and Jordan, E., Proc. US Nat. Acad. Sci. (in the press).
Kedes, L., and Birnstiel, M., Nature New Biology, 230, 165 (1971).
Sutton, W., and McCallum, M., Nature New Biology, 232, 83 (1971).
Williamson, R., Morrison, M., Lanyon, G., Eason, R., and Paul, J., Biochemistry, 10, 3014 (1971).
Subak-Sharpe, J. H., Handbook of Molecular Cytology (edit. by Lima-de-Faria, A.), 67 (North Holland, Amsterdam, 1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PAUL, J. General Theory of Chromosome Structure and Gene Activation in Eukaryotes. Nature 238, 444–446 (1972). https://doi.org/10.1038/238444a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/238444a0
This article is cited by
-
That 70s show: regulation, evolution and development beyond molecular genetics
History and Philosophy of the Life Sciences (2015)
-
Interbands behave as decompacted autonomous units in Drosophila melanogaster polytene chromosomes
Genetica (2008)
-
Molecular and genetic organization of Drosophila melanogasterpolytene chromosomes: evidence for two types of interband regions
Genetica (2004)
-
Cloning and molecular genetic analysis of Drosopbila melanogaster interband DNA
Molecular and General Genetics MGG (1993)
-
The fourth chromosome of Chironomus tentans malpighian tubules
Chromosoma (1982)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
