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Stereochemical Requirements of the Mescaline Receptor


THIS report describes some psychopharmacological properties of two conformationally restricted analogues of the psychotomimetic compound mescaline(I). The geometrical distinction between these cis (IIa) and trans (IIb) isomers of 2-(3,4,5-trimethoxyphenyl)-cyclopropylamine makes it possible to examine possible Stereochemical preferences of the receptor for mescaline and other hallucinogenic phenethylamines.

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COOPER, P., WALTERS, G. Stereochemical Requirements of the Mescaline Receptor. Nature 238, 96–98 (1972).

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