Letter | Published:

Probable Genetic Linkage between Human Serum Amylase (Amy2) and Duffy Blood Group

Abstract

HUMAN serum amylase polymorphism was reported in detail by Kamarýt and Laxová1. Two loci, with codominant alleles, control four different isoamylases in man which are detectable in serum by agar gel electrophoresis. The first locus, Amy1, controls serum salivary isoamylase. The two salivary alleles are Amy1A, the most frequent in the population, and Amy1B. A possible third allele, Amy1C, results in the apparent silent salivary isoamylase in the serum or urine. The second locus, Amy2, controls serum pancreatic isoamylase. The two pancreatic alleles are Amy2A, the most frequently observed, and Amy2B. A search for linkage between Amy2 and Duffy (Fy) was suggested by the finding of probable linkage between Amy2 and the uncoiler region on chromosome 1 (UN-1) by Kamarýt et al.6 and the previous finding of linkage between Duffy and UN-1 by Donahue et al.7.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Kamarýt, J., and Laxov´, R., Humangenetik, 1, 579 (1965).

  2. 2

    Norby, S., Exp. Cell Res., 36, 663 (1964).

  3. 3

    Smith, C. A. B., Ann. Human Genet., 32, 127 (1968).

  4. 4

    Smith, C. A. B., Amer. J. Human Genet., 11, 289 (1959).

  5. 5

    Renwick, J. H., Brit. Med. Bull., 25, 65 (1969).

  6. 6

    Kamarýt, J., Ad´mek, R., and Vrba, M., Humangenetik, 11, 213 (1971).

  7. 7

    Donahue, R. P., Bias, W. B., Renwick, J. H., and McKusick, V. A., Proc. US Nat. Acad. Sci., 61, 949 (1968).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.