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Probable Genetic Linkage between Human Serum Amylase (Amy2) and Duffy Blood Group


HUMAN serum amylase polymorphism was reported in detail by Kamarýt and Laxová1. Two loci, with codominant alleles, control four different isoamylases in man which are detectable in serum by agar gel electrophoresis. The first locus, Amy1, controls serum salivary isoamylase. The two salivary alleles are Amy1A, the most frequent in the population, and Amy1B. A possible third allele, Amy1C, results in the apparent silent salivary isoamylase in the serum or urine. The second locus, Amy2, controls serum pancreatic isoamylase. The two pancreatic alleles are Amy2A, the most frequently observed, and Amy2B. A search for linkage between Amy2 and Duffy (Fy) was suggested by the finding of probable linkage between Amy2 and the uncoiler region on chromosome 1 (UN-1) by Kamarýt et al.6 and the previous finding of linkage between Duffy and UN-1 by Donahue et al.7.

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  1. 1

    Kamarýt, J., and Laxov´, R., Humangenetik, 1, 579 (1965).

  2. 2

    Norby, S., Exp. Cell Res., 36, 663 (1964).

  3. 3

    Smith, C. A. B., Ann. Human Genet., 32, 127 (1968).

  4. 4

    Smith, C. A. B., Amer. J. Human Genet., 11, 289 (1959).

  5. 5

    Renwick, J. H., Brit. Med. Bull., 25, 65 (1969).

  6. 6

    Kamarýt, J., Ad´mek, R., and Vrba, M., Humangenetik, 11, 213 (1971).

  7. 7

    Donahue, R. P., Bias, W. B., Renwick, J. H., and McKusick, V. A., Proc. US Nat. Acad. Sci., 61, 949 (1968).

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