Letter | Published:

α-Foetoprotein in Normal Human Serum

Abstract

α-FOETOPROTEIN (α-FP) has been considered specific for the foetal and neonatal periods1,2 and for certain types of malignant tumours3,4. The occurrence of α-FP in viral hepatitis has recently been reported5,6. The presence of α-FP in malignant disease is usually thought to result from derepression of a foetal gene that is normally suppressed at the adult stage. We now report the detection of α-FP in sera of healthy non-pregnant human adults. The presence of α-FP in adult sera was demonstrated by radioimmunoassay (RIA) and confirmed by RIA of concentrated α-FP preparations from normal human serum using immunoadsorbents.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Bergstrand, C. G., and Czar, B., Scand. J. Clin. Lab. Invest., 8, 174 (1956).

  2. 2

    Gitlin, D., and Boesman, M., J. Clin. Invest., 45, 1826 (1966).

  3. 3

    Tatarinov, Y. S., Vop. Med. Khim., 11, 20 (1965).

  4. 4

    Abelev, G. I., Assercritova, I. V., Karevsky, N. A., Perova, S. D., and Perevodchikova, N. I., Intern. J. Cancer, 2, 551 (1967).

  5. 5

    Abelev, G. I., Tsvetkov, V. S., Bryulina, T. I., Elgort, D. A., Olovnikov, A. M., Gusev, A. I., Yazova, A. K., Perova, S. D., Rubtsov, I. V., Shaborina, S. V., Kautorovich, B. A., Tur, V. M., Khazanov, A. I., and Levina, D. M., Biull. Eksper. Biol. Med., 4, 75 (1971).

  6. 6

    Geffroy, Y., Denis, P., Colin, R., Sauger, F., Matroy, F., and Fondimare, A., Presse Méd., 78, 1107 (1970).

  7. 7

    Ruoslahti, E., and Seppälä, M., Intern. J. Cancer, 7, 218 (1971).

  8. 8

    Greenwood, F. C., Hunter, W. M., and Glower, J. S., Biochem. J., 89, 114 (1963).

  9. 9

    Ruoslahti, E., and Seppälä, M., Intern. J. Cancer (in the press).

  10. 10

    Purves, L. R., Bersohn, I., and Geddes, E. W., Cancer, 25, 1261 (1970).

  11. 11

    Avrameas, S., and Ternynck, T., Immunochemistry, 6, 53 (1969).

  12. 12

    Martin, F., and Martin, M. S., Intern. J. Cancer, 6, 352 (1970).

  13. 13

    Gold, P., and Freedman, S. O., J. Exp. Med., 121, 439 (1965).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.