Regulation of Cell Motility by Cyclic AMP

Abstract

FIBROBLASTS exhibit a locomotory behaviour in cultures on a plane surface. An undulating membrane or leading lamella forms at the frontal edge and may be the locomotory organ of the cell. When the leading lamellae of two cells collide, several events occur. The forward motion of the cells is stopped, the cells contract, the undulations of the membrane cease, and movement proceeds in a different direction. This has been termed contact inhibition of movement1. When cells become confluent, movement is considerably decreased, presumably due to contact on all surfaces, and at confluency there are restrictions on cell growth which are apparently related to the population density of the cells. This has been termed contact or density-dependent inhibition of growth2–4. At present, no strong evidence connects contact inhibition of movement and growth, but as transformation often disturbs both properties a connexion between them may exist3,5.

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JOHNSON, G., MORGAN, W. & PASTAN, I. Regulation of Cell Motility by Cyclic AMP. Nature 235, 54–56 (1972). https://doi.org/10.1038/235054a0

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