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Temperature-sensitive Mutants of Adenovirus defective in Interferon Induction at Non-permissive Temperature

Abstract

SEVERAL different types of human adenoviruses induce interferon in chick embryo cells1,2 and it has been proposed that the penton antigen of the virus is responsible for this1. The evidence supporting this hypothesis, however, depends chiefly on sensitivity to trypsin, and in our opinion the adenovirus functions responsible for inducing interferon have not been clearly identified. We have isolated temperature-sensitive (ts) mutants of adenovirus type 53, which provided us with a possible system for identifying these functions. With this view in mind, we have tested ten ts mutants, classified into nine complementation groups4, for their ability to induce interferon in chick embryo cells at both the permissive (31° C) and non-permissive (38° C) temperatures. This brief communication presents evidence that two of these mutants, which complement each other in their ts functions, do not induce interferon at the non-permissive temperature, but induce it at the permissive temperature.

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References

  1. 1

    Béládi, I., and Pusztai, R., Z. Naturforsch., 22 b, 165 (1967).

  2. 2

    Ho, M., and Kohler, K., Archiv. für die Gesamte Virusforschung, 22, 69 (1967).

  3. 3

    Williams, J. F., Gharpure, M., Ustacelebi, S., and McDonald, S., J. Gen. Virol., 11, 95 (1971).

  4. 4

    Williams, J. F., and Ustacelebi, S., J. Gen. Virol. (in the press).

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