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Lysosomes, pH and the Anti-malarial Action of Chloroquine

Abstract

MALARIA parasites1 or mammalian liver2 suitably exposed to chloroquine rapidly form autophagic vacuoles; in the case of the parasites, these are visible under the light microscope because they contain clumps of pigment, the remains of haemoglobin digestion (Fig. 1). These striking morphological changes are well known but not correspondingly well understood.

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