Letter | Published:

Multiple Alpha Chain Loci for Human Haemoglobins: Hb J-Buda and Hb G-Pest


IT is well established that at least two independent loci control the structure of human haemoglobin A1,2. Although the primary structure of the β-chain is determined by a single genetic locus, there are conflicting reports that the α-chain is controlled by one3 or two4,5 loci. We now describe genetic and chemical studies of a Budapest family which possess two abnormal α-chain haemoglobins, Hb J-Buda and Hb G-Pest, and review evidence for multiple loci for the α-chain.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Additional information

Reprint requests should be sent either to Dr S. R. Hollan, National Institute of Haematology and Blood Transfusion, Budapest, Hungary, or to Dr R. T. Jones, Department of Biochemistry, University of Oregon Medical School, Portland, Oregon 97201.


  1. 1

    Smith, E. W., and Torbert, J. V., Bull. Johns Hopkins Hosp., 101, 38 (1958).

  2. 2

    Huehns, E. R., and Shooter, E. M., J. Med. Genet., 2, 48 (1965).

  3. 3

    Abramson, R. K., Rucknagel, D. L., Shreffler, D. C., and Saave, J. J., Science, 169, 194 (1970).

  4. 4

    Lehmann, H., and Carrell, R. W., Brit. Med. J., 4, 748 (1968).

  5. 5

    Brimhall, B., Hollan, S., Jones, R. T., Koler, R. D., Stocklen, Z., and Szelenyi, J. G., Clin. Res., 18, 184 (1970).

  6. 6

    Huisman, T. H. J., Adv. Clin. Chem., 6, 231 (1963).

  7. 7

    Huisman, T. H. J., and Dozy, A. M., J. Chromatog., 19, 160 (1965).

  8. 8

    Itano, H. A., Singer, S. J., and Robinson, E., in Biochemistry of Human Genetics, Ciba Foundation Symp. (edit. by Wolstenholme, G. E. W., and O'Connor, C. M.), 96 (Churchill, London, 1959).

  9. 9

    Huehns, E. R., Shooter, E. M., and Beaven, G. H., J. Mol. Biol., 4, 323 (1962).

  10. 10

    Clegg, J. B., Naughton, M. A., and Weatherall, D. J., J. Mol. Biol., 19, 91 (1966).

  11. 11

    Efremov, G. D., Huisman, T. H. J., Smith, L. L., Wilson, J. B., Kitchens, J. I., Wrightstone, R. N., and Adams, H. R., J. Biol. Chem., 244, 6105 (1969).

  12. 12

    Itano, H. A., and Robinson, E. A., Proc. US Nat. Acad. Sci., 46, 1492 (1960).

  13. 13

    Atwater, J., Schwartz, I. R., and Tocantins, L. M., Blood, 15, 901 (1960).

  14. 14

    Hummel, K., Schmidt, V., and Ihm, P., Z. Immun. Forsch., 137, 320 (1969).

  15. 15

    Kattamis, E., and Lehmann, H., Human Hered., 20, 156 (1970).

  16. 16

    Koler, R. D., Jones, R. T., Wasi, P., and Pootrukul, S., Ann. Human Genet., 34, 371 (1971).

  17. 17

    Adams, H. R., Wrightstone, R. N., Miller, A., and Huisman, T. H. J., Arch. Biochem. Biophys., 132, 223 (1969).

  18. 18

    Wade, P., Barnicot, N., and Huehns, E., Nature, 215, 1485 (1967).

  19. 19

    Wilson, J. B., Wrightstone, R. N., and Huisman, T. H. J., Nature, 226, 354 (1970).

  20. 20

    Oliver, E., and Kitchen, H., Biochem. Biophys. Res. Commun., 31, 749 (1968).

  21. 21

    Ranjekar, P. K., and Barnabas, J., Comp. Biochem. Physiol., 28, 1395 (1969).

  22. 22

    Hilse, K., and Popp, R. A., Proc. US Nat. Acad. Sci., 61, 930 (1968).

  23. 23

    Koler, R. D., and Rigas, D. A., Ann. Human Genet., 25, 95 (1961).

  24. 24

    Lehmann, H., Lancet, ii, 78 (1970).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.