Letter | Published:

Occurrence of Heterozygotes and Homozygotes for the α-Chain Haemoglobin Variant Hb-J(Tongariki) in New Guinea

Abstract

THE occurrence of the haemoglobin Hb-J(Tongariki) in new locations in the New Guinea area is of interest because this α-chain variant was the first to be found in Melanesian populations. Furthermore, the high proportion of the variant in heterozygotes and the discovery of three apparently homozygous subjects with Hb-J(Tongariki) as the sole major haemoglobin are relevant to current discussion concerning the possible duplication of the human α-chain gene locus.

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References

  1. 1

    Gajdusek, D. C., Guiart, J., Kirk, R. L., Carrell, R. W., Irvine, D., Kynoch, P. A. M., and Lehmann, H., J. Med. Genet., 4, 1 (1967).

  2. 2

    Booth, P. B., Vines, A. P., and Saave, J. J., Archeol. Phys. Anthropol. Oceania, 4, 115 (1969).

  3. 3

    Abramson, R. K., Rucknagel, D. L., Schreffler, D. C., and Saave, J. J., Science, 169, 194 (1970).

  4. 4

    Clegg, J. B., Naughton, M. A., and Weatherall, D. J., Nature, 207, 945 (1965).

  5. 5

    Huehns, E. R., in Chromatographic and Electrophoretic Techniques, second ed. (edit. by Smith, I.), 2, 291 (Heinemann, London, 1968).

  6. 6

    Gratzer, W. B., and Beaven, G. H., Clin. Chim. Acta, 5, 577 (1960).

  7. 7

    Gordon, A. H., in Laboratory Techniques in Biochemistry and Molecular Biology (edit. by Work, T. S. and Work, E.), 1, 123 (North-Holland, Amsterdam and London, 1969).

  8. 8

    Lehmann, H., and Carrell, R. W., Brit. Med. J., 4, 748 (1968).

  9. 9

    De Jong, W. W. W., Structural characterization of some mutants of human haemoglobin; including two new variants, thesis, Univ. Leiden (1969).

  10. 10

    Robinson, A. R., Robson, M., Harrison, A. P., and Zuelzer, W. W., J. Lab. Clin. Med., 50, 745 (1957).

  11. 11

    Gratzer, W. B., and Beaven, G. H., J. Chromatog., 5, 315 (1961).

  12. 12

    Brimhall, R., Hollan, S., Jones, R. T., Koler, R. D., and Szelenyi, J. G., Clin. Res., 18, 184 (1970).

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