Abstract
THREE protein preparations from the rat liver 100,000g supernatant fraction have been independently purified to homogeneity. They are basic azodye carcinogen-binding protein (β-ABP)1,2, corticosteroid Binder I3,4 and Y protein5. The compounds they bind include certain steroids and their metabolites, bilirubin and certain carcinogens and their metabolites. Several dyes and cholecystographic agents and other organic anions are also bound (Table 1). Binding occurs whether the compounds are injected in vivo or added in vitro to liver homogenates.
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LITWACK, G., KETTERER, B. & ARIAS, I. Ligandin: a Hepatic Protein which Binds Steroids, Bilirubin, Carcinogens and a Number of Exogenous Organic Anions. Nature 234, 466–467 (1971). https://doi.org/10.1038/234466a0
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DOI: https://doi.org/10.1038/234466a0
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