Abstract
IT is well known that genetic constitution modifies the effect of teratogenic agents (Table 1). The most obvious example is the varying susceptibility of different strains of mice to teratogens such as cortisone, 6-amino-nicotinamide and salicylates1–5. In A/Jax mice, for example cortisone induces cleft palate in 100% of living embryos (if those with spontaneous cleft lip-palate—about 10% of births—are excluded). Isolated cleft palate can be induced with cortisone in only about 20% of embryos in other strains such as C57B1 and CBA1,3.
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MARSK, L., THEORELL, M. & LARSSON, K. Transfer of Blastocysts as Applied in Experimental Teratology. Nature 234, 358–359 (1971). https://doi.org/10.1038/234358b0
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DOI: https://doi.org/10.1038/234358b0
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