Abstract
THE muscarinic excitatory action of acetylcholine on central and peripheral neurones has been suggested to involve a reduction in membrane conductance for potassium ions1,2. This proposal was supported by observations that 2,4-dinitrophenol (DNP) could specifically suppress the excitation by acetylcholine of cerebral cortical neurones in the cat without affecting the excitatory action of L-glutamate, and that the hyperpolarization of these neurones by DNP involved an increase in the membrane conductance for potassium ions3.
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Godfraind, J. M., Krnjević, K., and Pumain, R., Nature, 208, 562 (1970).
Krnjević, K., Pumain, R., and Renaud, L., J. Physiol., 215, 247 (1971).
Godfraind, J. M., Kawamura, H., Krnjević, K., and Pumain, R., J. Physiol., 215, 199 (1971).
Curtis, D. R., and Ryall, R. W., Exp. Brain Res., 2, 66 (1966).
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CURTIS, D., FELIX, D. Muscarinic Action of Acetylcholine. Nature 234, 355 (1971). https://doi.org/10.1038/234355a0
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DOI: https://doi.org/10.1038/234355a0
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