Abstract
AGENTS which cause metaphase arrest have been found to affect the rapid reversible darkening of frog skin under the influence of melanocyte-stimulating hormone (MSH)1,2. Darkening is caused largely by the dispersion of melanin granules in dermal melanocytes. After subsequent washing, the skin lightens and the melanin granules aggregate. In this system, preincubation with colchicine, colcemid, vinblastine or vincristine produces a slight increase in darkening induced by MSH, and a dosage-dependent inhibition of the subsequent lightening.
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MALAWISTA, S. Cytochalasin B Reversibly Inhibits Melanin Granule Movement in Melanocytes. Nature 234, 354–355 (1971). https://doi.org/10.1038/234354a0
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DOI: https://doi.org/10.1038/234354a0
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