Abstract
Haemoglobin Constant Spring is an unusual variant which comprises only 1–2% of the total haemoglobin in heterozygotes. It has α-chains which are 172 residues long instead of the normal 141, and when it is inherited together with an α-thalassaemia gene it gives rise to haemoglobin H disease.
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CLEGG, J., WEATHERALL, D. & MILNER, P. Haemoglobin Constant Spring—A Chain Termination Mutant ?. Nature 234, 337–340 (1971). https://doi.org/10.1038/234337a0
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DOI: https://doi.org/10.1038/234337a0
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