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Unique High Affinity Uptake Systems for Glycine, Glutamic and Aspartic Acids in Central Nervous Tissue of the Rat


NEUROPHYSIOLOGICAL experiments suggest that several aminoacids, especially glycine and glutamic, aspartic and gamma-aminobutyric (GABA) acids, are neurotransmitters in the central nervous system1–3. But careful subcellular4,5 and regional studies6–8 have not provided supporting neurochemical evidence, because ammo-acids, with the possible exception of GABA, also have general metabolic functions in nervous tissue.

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  1. Curtis, D. R., and Crawford, J. M., Ann. Rev. Pharmacol., 9, 209 (1969).

    Article  CAS  Google Scholar 

  2. Krnjevic, K., Nature, 228, 119 (1970).

    Article  ADS  CAS  Google Scholar 

  3. Werman, R., Davidoff, R. A., and Aprison, M. H., J. Neurophysiol., 31, 81 (1968).

    Article  CAS  Google Scholar 

  4. Mangan, J. L., and Whittaker, V. P., Biochem. J., 98, 128 (1966).

    Article  CAS  Google Scholar 

  5. Kuhar, M. J., and Snyder, S. H., J. Pharmacol. Exp. Ther., 171, 141 (1970).

    CAS  Google Scholar 

  6. Aprison, M. H., and Werman, R., Life Sci., 4, 2075 (1965).

    Article  CAS  Google Scholar 

  7. Graham, L. T., Shank, R. P., Werman, R., and Aprison, M. H., J. Neurochem., 14, 465 (1967).

    Article  CAS  Google Scholar 

  8. Duggan, A. W., and Johnston, G. A. R., J. Neurochem., 17, 1205 (1970).

    Article  CAS  Google Scholar 

  9. Iversen, L. L., The Uptake and Storage of Noradrenaline in Sympathetic Nerves (Cambridge University Press, London, 1967).

    Google Scholar 

  10. Coyle, J. T., and Snyder, S. H., J. Pharmacol. Exp. Ther., 170, 221 (1969).

    CAS  PubMed  Google Scholar 

  11. Blackburn, K. J., French, P. C., and Merrills, R. M., Life Sci., 6, 1653 (1967).

    Article  CAS  Google Scholar 

  12. Shaskan, E. G., and Snyder, S. H., J. Pharmacol. Exp. Ther., 175, 404 (1970).

    CAS  PubMed  Google Scholar 

  13. Roberts, E., and Kuriyama, K., Brain Res., 8, 1 (1968).

    Article  CAS  Google Scholar 

  14. Iversen, L. L., and Neal, M. J., J. Neurochem., 15, 1141 (1968).

    Article  CAS  Google Scholar 

  15. Blasberg, R. G., in Prog. Brain Res. (edit. by Lajtha, A., and Ford, D. H.), 29, 245 (Elsevier, Amsterdam, 1968).

    Google Scholar 

  16. Lineweaver, H., and Burk, D., J. Amer. Chem. Soc., 56, 658 (1934).

    Article  CAS  Google Scholar 

  17. Cleland, W. W., Adv. Enzymol., 29, 1 (1967).

    CAS  PubMed  Google Scholar 

  18. Dixon, M., Biochem. J., 55, 170 (1953).

    Article  CAS  Google Scholar 

  19. Hammerschlag, R., Potter, L. T., and Vinci, J., Trans. Amer. Soc. Neurochem., 2, 78 (1971).

    Google Scholar 

  20. Wofsey, A. R., Kuhar, M. J., and Snyder, S. H., Proc. US Nat. Acad. Sci. (in the press).

  21. Curtis, D. R., Hösli, L., and Johnson, G. A. R., Exp. Brain Res., 6, 1 (1968).

    Article  ADS  CAS  Google Scholar 

  22. Neal, M. J., and Pickles, H. G., Nature, 222, 679 (1969).

    Article  ADS  CAS  Google Scholar 

  23. Johnston, G. A. R., and Iversen, L. L., J. Neurochem. (in the press).

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LOGAN, W., SNYDER, S. Unique High Affinity Uptake Systems for Glycine, Glutamic and Aspartic Acids in Central Nervous Tissue of the Rat. Nature 234, 297–299 (1971).

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