Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Simplicity of Mammalian Regulatory Systems inferred by Single Gene Determination of Sex Phenotypes

Abstract

Dr Ohno predicts that mammalian regulatory systems will turn out to be less complex than is generally anticipated.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Jacob, F., and Monod, J., J. Mol. Biol., 3, 318 (1961).

    Article  CAS  Google Scholar 

  2. McKusick, V. A., Ann. Rev. Genet., 4, 1 (1970).

    Article  CAS  Google Scholar 

  3. Kimura, M., Genet. Res., 11, 247 (1968).

    Article  CAS  Google Scholar 

  4. Haldane, J. B. S., J. Genet., 55, 511 (1957).

    Article  Google Scholar 

  5. Muller, H. J., in Heritage from Mendel (edit. by Brink, R. A.), 419 (University of Wisconsin Press, Madison, 1967).

    Google Scholar 

  6. Crow, F., and Kimura, M., An Introduction to Population Genetics Theory (Harper and Row, New York, 1970).

    MATH  Google Scholar 

  7. Editorial, Nature New Biology, 231, 68 (1971).

  8. Lyon, M. F., Nature, 190, 372 (1961).

    Article  ADS  CAS  Google Scholar 

  9. Robinson, G. A., Butcher, R. W., and Sutherland, E. W., Ann. Rev. Biochem., 37, 149 (1968).

    Article  Google Scholar 

  10. Jost, A., The Harvey Lectures, Series 55 (Academic Press, New York, 1961).

    Google Scholar 

  11. Morris, J. M., Amer. J. Obstet. Gynec., 65, 1192 (1953).

    Article  CAS  Google Scholar 

  12. Polani, P. E., Phil. Trans. Roy. Soc., B, 259, 187 (1970).

    Article  ADS  CAS  Google Scholar 

  13. Short, R. V., Ann. Rev. Physiol., 29, 373 (1967).

    Article  CAS  Google Scholar 

  14. Stanley, A. J., and Gumbreck, L. G., programme, Endocrinology Society, 40 (1964).

  15. Lyon, M. F., and Hawkes, S. G., Nature, 227, 1217 (1970).

    Article  ADS  CAS  Google Scholar 

  16. David, R. R., Wiemer, M., Ross, L., and Landau, R. L., J. Clin. Endocrinol., 25, 1393 (1965).

    Article  CAS  Google Scholar 

  17. Schneider, G., and Bardin, C. W., Endocrinology, 87, 864 (1970).

    Article  CAS  Google Scholar 

  18. Ohno, S., Ann. Rev. Genet., 3, 495 (1969).

    Article  Google Scholar 

  19. Jagiello, G., and Atwell, J. D., Lancet, i, 329 (1962).

  20. Bullock, L., and Bardin, C. W., J. Clin. Endocrinol. Metabolism, 31, 113 (1970).

    Article  CAS  Google Scholar 

  21. Ohno, S., and Lyon, M. F., Clin. Genet., 1, 121 (1970).

    Article  CAS  Google Scholar 

  22. Dofuku, R., Tettenborn, U., and Ohno, S., Nature New Biology (in the press).

  23. Ohno, S., Dofuku, R., and Tettenborn, U., Clin. Genet., 2, 1 (1971).

    Google Scholar 

  24. Gehring, U., Tomkins, G. M., and Ohno, S., Nature New Biology, 232, 106 (1971).

    Article  CAS  Google Scholar 

  25. Tomkins, G. M., Gelehrter, T. D., Granner, D., Martin, D., Samuels, H. H., and Thompson, E. B., Science, 166, 1474 (1969).

    Article  ADS  CAS  Google Scholar 

  26. Liao, S., and Stumpf, W. E., Endocrinology, 83, 629 (1968).

    Article  CAS  Google Scholar 

  27. Liao, S., Leininger, K. R., Sagher, D., and Barton, R. W., Endocrinology, 77, 763 (1965).

    Article  CAS  Google Scholar 

  28. Roeder, R. G., and Rutter, W. J., Nature, 224, 234 (1969).

    Article  ADS  CAS  Google Scholar 

  29. Blatti, S. P., Ingles, C. J., Lindell, T. J., Morris, P. W., Weaver, R. F., Weinberg, F., and Rutter, W. J., Cold Spring Harbor Symp. Quant. Biol., 35, 649 (1970).

    Article  CAS  Google Scholar 

  30. Bruchovsky, N., and Wilson, J. D., J. Biol. Chem., 243, 5953 (1968).

    CAS  PubMed  Google Scholar 

  31. Fang, S., Anderson, K. M., and Liao, S., J. Biol. Chem., 244, 6584 (1969).

    CAS  PubMed  Google Scholar 

  32. Neumann, F., Elger, W., and Steinbeck, H., J. Reprod. Fert., 7, 9 (1969).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

OHNO, S. Simplicity of Mammalian Regulatory Systems inferred by Single Gene Determination of Sex Phenotypes. Nature 234, 134–137 (1971). https://doi.org/10.1038/234134a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/234134a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing