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Potentiation of Amphetamine-induced Arousal by Starvation


STARVATION and amphetamine both increase behavioural arousal, and have been postulated to act through adrenergic mechanisms in the brain stem. Amphetamine is believed to induce psychomotor excitation by releasing brain catecholamines, blocking their re-uptake from the synapse and mildly inhibiting the action of the catabolizing enzyme, monoamine oxidase1–3. The drug also accelerates the turnover of nor-adrenaline in the brain stem reticular formation4. Food deprivation increases electrophysiological arousal in the mesencephalic reticular formation and other areas5 and Dell6 postulated that behavioural arousal induced by starvation resulted from the release of catecholamines from the adrenal medulla and their consequent action on brain stem excitatory areas.

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  1. Glowinski, J., and Axelrod, J., Pharmacol. Rev., 18, 775 (1966).

    CAS  PubMed  Google Scholar 

  2. Glowinski, J., and Baldessarini, R. J., Pharmacol Rev., 18, 1201 (1966).

    CAS  PubMed  Google Scholar 

  3. Carr, L. A., and Moore, K. E., Science, 164, 322 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Javoy, F., Thierry, A. M., Kety, S. S., and Glowinski, J., Commun. Behav. Biol., 1, 43 (1968).

    Google Scholar 

  5. Hockman, C. H., Electroenceph. Clin. Neurophysiol., 17, 420 (1964).

    Article  CAS  PubMed  Google Scholar 

  6. Dell, P. C., in Neurological Basis of Behavior (edit. by Wolstenholme, G. E. W., and O'Conner, M.) (Churchill, London, 1958).

    Google Scholar 

  7. Campbell, B. A., in Thirst (edit. by Wayner, M.) (Pergamon, New York, 1964).

    Google Scholar 

  8. Angel, C., Dis. Nerv. Sys., 30, 94 (1969).

    CAS  Google Scholar 

  9. Dixon, R. L., Shunttice, R. W., and Fouts, J. R., Fed. Proc., 103, 333 (1960).

    CAS  Google Scholar 

  10. Bliss, E. L., Ailion, J., and Zwanzieger, J., J. Pharmacol. Exp. Ther., 164, 122 (1968).

    CAS  PubMed  Google Scholar 

  11. Gordon, R., Spector, S., Sjoerdsma, A., and Udenfriend, S., J. Pharmacol. Exp. Ther., 153, 440 (1966).

    CAS  PubMed  Google Scholar 

  12. Maynert, E. W., and Levi, R., J. Pharmacol. Exp. Ther., 143, 90 (1969).

    Google Scholar 

  13. Corrodi, H., Fuxe, K., and Hokfelt, T., Life Sci., 7, 107 (1968).

    Article  CAS  PubMed  Google Scholar 

  14. Weiss, B., Laties, V. G., and Blanton, F. L., J. Pharmacol. Exp. Ther., 132, 366 (1961).

    CAS  PubMed  Google Scholar 

  15. Goldberg, M. E., and Salama, A. I., Toxicol. Appl. Pharmacol., 14, 447 (1969).

    Article  CAS  PubMed  Google Scholar 

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CAMPBELL, B., FIBIGER, H. Potentiation of Amphetamine-induced Arousal by Starvation. Nature 233, 424–425 (1971).

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