Abstract
Atomic positions in three dimensions have been derived for the two non-identical molecules of insulin in rhombohedral 2-zinc insulin crystals. Interesting correlations appear in their relation to the sequence variations observed so far in natural insulins.
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References
Adams, M. J., Blundell, T. L., Dodson, E. J., Dodson, G. G., Vijayan, M., Baker, E. N., Harding, M. M., Hodgkin, D. C., Rimmer, B., and Sheat, S., Nature, 224, 491 (1969).
Blundell, T. L., Dodson, E. J., Dodson, G. G., Hodgkin, D. C., and Vijayan, M., Recent Prog. Hormone Res., 20, 1 (Academic Press, New York, 1971).
Richards, F. M., J. Mol. Biol. 37, 225 (1968).
Diamond, R. D., Acta Cryst., 21, 253 (1966).
Brill, A. S., and Venable, J. H., J. Mol. Biol., 36, 343 (1968).
Dayoff, M. O., and Eck, R. V., Atlas of Protein Sequence and Structure (National Biomedical Research Foundation, Silver Springs, Maryland, 1970).
Smith, L. F., Amer. J. Med., 40, 662 (1966).
Carpenter, F. H., Amer. J. Med., 40, 750 (1966).
Pikl, E., and Falkmer, O., Excerpta Medica, 140, 98 (1967).
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BLUNDELL, T., CUTFIELD, J., CUTFIELD, S. et al. Atomic Positions in Rhombohedral 2-Zinc Insulin Crystals. Nature 231, 506–511 (1971). https://doi.org/10.1038/231506a0
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DOI: https://doi.org/10.1038/231506a0
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